Elevated Muscle Sympathetic Nerve Activity Contributes to Central Artery Stiffness in Young and Middle-Age/Older Adults
Muscle sympathetic nerve activity (MSNA) influences the mechanical properties (ie, vascular smooth muscle tone and stiffness) of peripheral arteries, but it remains controversial whether MSNA contributes to stiffness of central arteries, such as the aorta and carotids. We examined whether elevated M...
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Published in | Hypertension (Dallas, Tex. 1979) Vol. 73; no. 5; pp. 1025 - 1035 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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United States
American Heart Association, Inc
01.05.2019
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Subjects | |
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Abstract | Muscle sympathetic nerve activity (MSNA) influences the mechanical properties (ie, vascular smooth muscle tone and stiffness) of peripheral arteries, but it remains controversial whether MSNA contributes to stiffness of central arteries, such as the aorta and carotids. We examined whether elevated MSNA (age-related) would be independently associated with greater stiffness of central (carotid-femoral pulse wave velocity [PWV]) and peripheral (carotid-brachial PWV) arteries, in addition to lower carotid compliance coefficient, in healthy men and women (n=88, age19–73 years, 52% men). We also examined whether acute elevations in MSNA without increases in mean arterial pressure using graded levels of lower body negative pressure would augment central and peripheral artery stiffness in young (n=15, 60% men) and middle-age/older (MA/O, n=14, 43% men) adults. Resting MSNA burst frequency (bursts·min) was significantly correlated with carotid-femoral PWV (R=0.44, P<0.001), carotid-brachial PWV (R=0.32, P=0.004), and carotid compliance coefficient (R=0.28, P=0.01) after controlling for sex, mean arterial pressure, heart rate, and waist-to-hip ratio (central obesity), but these correlations were abolished after further controlling for age (all P>0.05). In young and MA/O adults, MSNA was elevated during lower body negative pressure (P<0.001) and produced significant increases in carotid-femoral PWV (youngΔ+1.3±0.3 versus MA/OΔ+1.0±0.3 m·s, P=0.53) and carotid-brachial PWV (youngΔ+0.7±0.3 versus MA/OΔ+0.7±0.5 m·s, P=0.92), whereas carotid compliance coefficient during lower body negative pressure was significantly reduced in young but not MA/O (youngΔ−0.04±0.01 versus MA/OΔ0.001±0.008 mm·mm Hg, P<0.01). Collectively, these data demonstrate the influence of MSNA on central artery stiffness and its potential contribution to age-related increases in stiffness of both peripheral and central arteries. |
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AbstractList | Muscle sympathetic nerve activity (MSNA) influences the mechanical properties (ie, vascular smooth muscle tone and stiffness) of peripheral arteries, but it remains controversial whether MSNA contributes to stiffness of central arteries, such as the aorta and carotids. We examined whether elevated MSNA (age-related) would be independently associated with greater stiffness of central (carotid-femoral pulse wave velocity [PWV]) and peripheral (carotid-brachial PWV) arteries, in addition to lower carotid compliance coefficient, in healthy men and women (n=88, age: 19–73 years, 52% men). We also examined whether acute elevations in MSNA without increases in mean arterial pressure using graded levels of lower body negative pressure would augment central and peripheral artery stiffness in young (n=15, 60% men) and middle-age/older (MA/O, n=14, 43% men) adults. Resting MSNA burst frequency (bursts·min
−1
) was significantly correlated with carotid-femoral PWV (
R
=0.44,
P
<0.001), carotid-brachial PWV (
R
=0.32,
P
=0.004), and carotid compliance coefficient (
R
=0.28,
P
=0.01) after controlling for sex, mean arterial pressure, heart rate, and waist-to-hip ratio (central obesity), but these correlations were abolished after further controlling for age (all
P
>0.05). In young and MA/O adults, MSNA was elevated during lower body negative pressure (
P
<0.001) and produced significant increases in carotid-femoral PWV (young: Δ+1.3±0.3 versus MA/O: Δ+1.0±0.3 m·s
−1
,
P
=0.53) and carotid-brachial PWV (young: Δ+0.7±0.3 versus MA/O: Δ+0.7±0.5 m·s
−1
,
P
=0.92), whereas carotid compliance coefficient during lower body negative pressure was significantly reduced in young but not MA/O (young: Δ−0.04±0.01 versus MA/O: Δ0.001±0.008 mm
2
·mm Hg
−1
,
P
<0.01). Collectively, these data demonstrate the influence of MSNA on central artery stiffness and its potential contribution to age-related increases in stiffness of both peripheral and central arteries. Muscle sympathetic neural activity (MSNA) influences the mechanical properties (i.e., vascular smooth muscle tone and stiffness) of peripheral arteries, but it remains controversial whether MSNA contributes to stiffness of central arteries such as the aorta and carotids. We examined whether elevated MSNA (age-related) would be independently associated with greater stiffness of central [carotid-femoral pulse wave velocity (PWV)] and peripheral (carotid-brachial PWV) arteries, in addition to lower carotid compliance coefficient (CC), in healthy men and women (n=88, age:19-73 years, 52%men). Also, we examined whether acute elevations in MSNA without increases in mean arterial pressure (MAP) using graded levels of lower body negative pressure (LBNP) would augment central and peripheral artery stiffness in young (YG, n=15, 60%men) and middle-age/older adults (MA/O, n=14, 43%men). Resting MSNA burst frequency (bursts·min −1 ) was significantly correlated with carotid-femoral PWV (R=0.44, P<0.001), carotid-brachial PWV (R=0.32, P=0.003), and carotid CC (R=0.28, P=0.01) after controlling for sex, MAP, heart rate, and waist-to-hip ratio (central obesity), but these correlations were abolished after further controlling for age (all P>0.05). In YG and MA/O adults, MSNA was elevated during LBNP (P<0.001) and produced significant increases in carotid-femoral PWV (YG:Δ+1.3±0.3 vs. MA/O:Δ+1.0±0.3 m·s −1 , P=0.53) and carotid-brachial PWV (YG: Δ+0.7±0.3 vs. MA/O: Δ+0.7±0.5 m·s −1 , P=0.92), whereas carotid CC during LBNP was significantly reduced in YG but not MA/O (YG:Δ-0.04 ±0.01 vs. MA/O:Δ0.001±0.008 mm 2 ·mmHg −1 , P<0.01). Collectively, these data demonstrate the influence of MSNA on central artery stiffness and its potential contribution to age-related increases in stiffness of both peripheral and central arteries. Our findings demonstrate the influence of MSNA on central artery stiffness and its potential contribution to age-related increases in stiffness of both peripheral and central arteries. Muscle sympathetic nerve activity (MSNA) influences the mechanical properties (ie, vascular smooth muscle tone and stiffness) of peripheral arteries, but it remains controversial whether MSNA contributes to stiffness of central arteries, such as the aorta and carotids. We examined whether elevated MSNA (age-related) would be independently associated with greater stiffness of central (carotid-femoral pulse wave velocity [PWV]) and peripheral (carotid-brachial PWV) arteries, in addition to lower carotid compliance coefficient, in healthy men and women (n=88, age19–73 years, 52% men). We also examined whether acute elevations in MSNA without increases in mean arterial pressure using graded levels of lower body negative pressure would augment central and peripheral artery stiffness in young (n=15, 60% men) and middle-age/older (MA/O, n=14, 43% men) adults. Resting MSNA burst frequency (bursts·min) was significantly correlated with carotid-femoral PWV (R=0.44, P<0.001), carotid-brachial PWV (R=0.32, P=0.004), and carotid compliance coefficient (R=0.28, P=0.01) after controlling for sex, mean arterial pressure, heart rate, and waist-to-hip ratio (central obesity), but these correlations were abolished after further controlling for age (all P>0.05). In young and MA/O adults, MSNA was elevated during lower body negative pressure (P<0.001) and produced significant increases in carotid-femoral PWV (youngΔ+1.3±0.3 versus MA/OΔ+1.0±0.3 m·s, P=0.53) and carotid-brachial PWV (youngΔ+0.7±0.3 versus MA/OΔ+0.7±0.5 m·s, P=0.92), whereas carotid compliance coefficient during lower body negative pressure was significantly reduced in young but not MA/O (youngΔ−0.04±0.01 versus MA/OΔ0.001±0.008 mm·mm Hg, P<0.01). Collectively, these data demonstrate the influence of MSNA on central artery stiffness and its potential contribution to age-related increases in stiffness of both peripheral and central arteries. Muscle sympathetic nerve activity (MSNA) influences the mechanical properties (ie, vascular smooth muscle tone and stiffness) of peripheral arteries, but it remains controversial whether MSNA contributes to stiffness of central arteries, such as the aorta and carotids. We examined whether elevated MSNA (age-related) would be independently associated with greater stiffness of central (carotid-femoral pulse wave velocity [PWV]) and peripheral (carotid-brachial PWV) arteries, in addition to lower carotid compliance coefficient, in healthy men and women (n=88, age: 19-73 years, 52% men). We also examined whether acute elevations in MSNA without increases in mean arterial pressure using graded levels of lower body negative pressure would augment central and peripheral artery stiffness in young (n=15, 60% men) and middle-age/older (MA/O, n=14, 43% men) adults. Resting MSNA burst frequency (bursts·min ) was significantly correlated with carotid-femoral PWV ( R=0.44, P<0.001), carotid-brachial PWV ( R=0.32, P=0.004), and carotid compliance coefficient ( R=0.28, P=0.01) after controlling for sex, mean arterial pressure, heart rate, and waist-to-hip ratio (central obesity), but these correlations were abolished after further controlling for age (all P>0.05). In young and MA/O adults, MSNA was elevated during lower body negative pressure ( P<0.001) and produced significant increases in carotid-femoral PWV (young: Δ+1.3±0.3 versus MA/O: Δ+1.0±0.3 m·s , P=0.53) and carotid-brachial PWV (young: Δ+0.7±0.3 versus MA/O: Δ+0.7±0.5 m·s , P=0.92), whereas carotid compliance coefficient during lower body negative pressure was significantly reduced in young but not MA/O (young: Δ-0.04±0.01 versus MA/O: Δ0.001±0.008 mm ·mm Hg , P<0.01). Collectively, these data demonstrate the influence of MSNA on central artery stiffness and its potential contribution to age-related increases in stiffness of both peripheral and central arteries. |
Author | DuBose, Lyndsey Collins, Michael T Fadel, Paul J Pierce, Gary L Luehrs, Rachel E Holwerda, Seth W Wooldridge, Nealy A Abboud, Francois M Stroud, Amy K |
AuthorAffiliation | From the Department of Health and Human Physiology (S.W.H., R.E.L., M.T.C., N.A.W., G.L.P.) Abboud Cardiovascular Research Center (S.W.H., F.M.A., G.L.P.) Department of Psychiatry (A.K.S.) Department of Internal Medicine (F.M.A.) Department of Molecular Physiology and Biophysics (F.M.A.) Fraternal Order of Eagles Diabetes Research Center (G.L.P.) University of Iowa (L.D.) Department of Kinesiology, University of Texas at Arlington (P.J.F.) |
AuthorAffiliation_xml | – name: From the Department of Health and Human Physiology (S.W.H., R.E.L., M.T.C., N.A.W., G.L.P.) Abboud Cardiovascular Research Center (S.W.H., F.M.A., G.L.P.) Department of Psychiatry (A.K.S.) Department of Internal Medicine (F.M.A.) Department of Molecular Physiology and Biophysics (F.M.A.) Fraternal Order of Eagles Diabetes Research Center (G.L.P.) University of Iowa (L.D.) Department of Kinesiology, University of Texas at Arlington (P.J.F.) – name: 4 Department of Kinesiology, University of Texas at Arlington, Arlington, TX – name: 5 Department of Internal Medicine, University of Iowa, Iowa City, IA – name: 6 Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA – name: 1 Department of Health and Human Physiology, University of Iowa, Iowa City, IA – name: 2 Abboud Cardiovascular Research Center, University of Iowa, Iowa City, IA – name: 7 Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA – name: 3 Department of Psychiatry, University of Iowa, Iowa City, IA |
Author_xml | – sequence: 1 givenname: Seth surname: Holwerda middlename: W fullname: Holwerda, Seth W organization: From the Department of Health and Human Physiology (S.W.H., R.E.L., M.T.C., N.A.W., G.L.P.) Abboud Cardiovascular Research Center (S.W.H., F.M.A., G.L.P.) Department of Psychiatry (A.K.S.) Department of Internal Medicine (F.M.A.) Department of Molecular Physiology and Biophysics (F.M.A.) Fraternal Order of Eagles Diabetes Research Center (G.L.P.) University of Iowa (L.D.) Department of Kinesiology, University of Texas at Arlington (P.J.F.) – sequence: 2 givenname: Rachel surname: Luehrs middlename: E fullname: Luehrs, Rachel E – sequence: 3 givenname: Lyndsey surname: DuBose fullname: DuBose, Lyndsey – sequence: 4 givenname: Michael surname: Collins middlename: T fullname: Collins, Michael T – sequence: 5 givenname: Nealy surname: Wooldridge middlename: A fullname: Wooldridge, Nealy A – sequence: 6 givenname: Amy surname: Stroud middlename: K fullname: Stroud, Amy K – sequence: 7 givenname: Paul surname: Fadel middlename: J fullname: Fadel, Paul J – sequence: 8 givenname: Francois surname: Abboud middlename: M fullname: Abboud, Francois M – sequence: 9 givenname: Gary surname: Pierce middlename: L fullname: Pierce, Gary L |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30905199$$D View this record in MEDLINE/PubMed |
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PublicationPlace_xml | – name: United States |
PublicationTitle | Hypertension (Dallas, Tex. 1979) |
PublicationTitleAlternate | Hypertension |
PublicationYear | 2019 |
Publisher | American Heart Association, Inc |
Publisher_xml | – name: American Heart Association, Inc |
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Snippet | Muscle sympathetic nerve activity (MSNA) influences the mechanical properties (ie, vascular smooth muscle tone and stiffness) of peripheral arteries, but it... Muscle sympathetic neural activity (MSNA) influences the mechanical properties (i.e., vascular smooth muscle tone and stiffness) of peripheral arteries, but it... |
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SubjectTerms | Adult Aged Aging - physiology Aorta - physiology Arterial Pressure - physiology Brachial Artery - physiology Carotid Arteries - physiology Femoral Artery - physiology Humans Male Middle Aged Muscle, Smooth, Vascular - innervation Sympathetic Nervous System - physiology Vascular Stiffness - physiology Young Adult |
Title | Elevated Muscle Sympathetic Nerve Activity Contributes to Central Artery Stiffness in Young and Middle-Age/Older Adults |
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