Fibulin 3 peptides Fib3-1 and Fib3-2 are potential biomarkers of osteoarthritis

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 64; no. 7; pp. 2260 - 2267
• Main Authors: Henrotin, Yves, Gharbi, Myriam, Mazzucchelli, Gabriel, Dubuc, Jean-Emile, De Pauw, Edwin, Deberg, Michelle
• Format: Journal Article Web Resource
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.07.2012; Wiley; Wiley Subscription Services, Inc; John Wiley & Sons
• Subjects: Adult; Aged; Aged, 80 and over; Arthroplasty, Replacement, Knee; Biological and medical sciences; Biomarkers; Biomarkers - urine; Cartilage, Articular - metabolism; Chondrocytes - metabolism; Diseases of the osteoarticular system; Extracellular Matrix Proteins - urine; Female; Human health sciences; Humans; Joint replacement surgery; Knee Joint - metabolism; Knee Joint - surgery; Medical sciences; Miscellaneous. Osteoarticular involvement in other diseases; Osteoarthritis; Osteoarthritis, Knee - diagnosis; Osteoarthritis, Knee - surgery; Osteoarthritis, Knee - urine; Peptides; Proteomics; Rheumatology; Rhumatologie; Sciences de la santé humaine; Peptides; Diseases of the osteoarticular system; Rheumatology; Arthropathy; Biological marker; Degenerative disease; Osteoarthritis

Objective This study was undertaken to identify new biomarkers of osteoarthritis (OA) by proteomics analysis and to develop specific immunoassays to detect and quantify them. Methods Proteomics analysis was performed in urine samples from 10 women (mean ± SD age 76.0 ± 5.0 years) undergoing knee rep...