Chemically modified microRNA delivery via DNA tetrahedral frameworks for dental pulp regeneration

• Published in: Journal of nanobiotechnology Vol. 22; no. 1; pp. 150 - 18
• Main Authors: Wei, Xiaoling, Xu, Huaxing, Zhou, Mengqi, Zhou, Qiangqiang, Li, Mingqiang, Liu, Yuehua
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.04.2024; BioMed Central; BMC
• Subjects: Acids; Angiogenesis; Blood vessels; Care and treatment; Cell Differentiation; Cell migration; Cell Proliferation - physiology; Chemical properties; Dental Pulp; Dental pulp regeneration; Dental pulp stem cells; Dental research; Dentistry; Deoxyribonucleic acid; DNA; DNA - metabolism; Endothelial Cells; Gene expression; Health aspects; Human subjects; In vivo methods and tests; MicroRNA; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Nanomedicine; Nanostructure; Nucleic acid modifications; Nucleic acids; Paracrine signalling; Pharmacology; Regeneration; Regeneration (physiology); Regenerative medicine; Ribonucleic acid; RNA; RNA processing; Stem Cells; Teeth; Tetrahedral-framework nucleic acid nanostructure; Tissue engineering; Tooth diseases; Wound healing; China; Dental pulp regeneration; Nucleic acid modifications; Angiogenesis; Tetrahedral-framework nucleic acid nanostructure; Dental pulp stem cells

Dental pulp regeneration is a promising strategy for addressing tooth disorders. Incorporating this strategy involves the fundamental challenge of establishing functional vascular networks using dental pulp stem cells (DPSCs) to support tissue regeneration. Current therapeutic approaches lack effici...