The significant role of amino acid metabolic reprogramming in cancer

• Published in: Cell communication and signaling Vol. 22; no. 1; pp. 380 - 26
• Main Authors: Liu, Xiaohong, Ren, Bo, Ren, Jie, Gu, Minzhi, You, Lei, Zhao, Yupei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 29.07.2024; BioMed Central; BMC
• Subjects: Adenosine; Amino acid metabolism; Amino acids; Amino Acids - metabolism; Analysis; Angiogenesis; Animals; Apoptosis; Biology; Biosynthesis; Cancer; Cancer therapies; Carbon; Care and treatment; Cell growth; Cellular Reprogramming; Colorectal cancer; Dehydrogenases; Development and progression; Diagnosis; Drug resistance; Enzymes; Epigenetic inheritance; Epigenetic regulation; Epigenetics; Extracellular matrix; Health aspects; Homeostasis; Humans; Immune response; Immune tolerance; Immunological tolerance; Immunomodulation; Kinases; Medical prognosis; Metabolic Reprogramming; Metabolism; Metabolites; Metastases; Metastasis; Neoplasms - metabolism; Neoplasms - pathology; Nitrogen; Oxidative metabolism; Oxidative stress; Phosphorylation; Physiological aspects; Polyamines; Protein biosynthesis; Protein synthesis; Protein turnover; Proteins; Redox; Review; Stromal cells; Tumor cells; Tumor Microenvironment; Tumors; China; Redox; Angiogenesis; Epigenetic regulation; Tumor microenvironment; Amino acid metabolism; Immune tolerance

Amino acid metabolism plays a pivotal role in tumor microenvironment, influencing various aspects of cancer progression. The metabolic reprogramming of amino acids in tumor cells is intricately linked to protein synthesis, nucleotide synthesis, modulation of signaling pathways, regulation of tumor c...