Angiotensin-converting enzyme 2 (ACE2) polymorphisms and susceptibility of severe SARS-CoV-2 in a subset of Pakistani population

• Published in: Virology journal Vol. 20; no. 1; p. 120
• Main Authors: Sidhwani, Santosh Kumar, Mirza, Talat, Khatoon, Ambrina, Shaikh, Fouzia, Khan, Rizma, Shaikh, Omer Ahmed, Nashwan, Abdulqadir J
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 12.06.2023; BioMed Central; BMC
• Subjects: ACE inhibitors; ACE2; ACE2 gene; Analysis; Angiotensin; Angiotensin converting enzyme; Angiotensin-Converting Enzyme 2; Asian people; Asymptomatic; Cardiovascular disease; COVID-19; Cross-Sectional Studies; Diabetes; Diabetics; Disease transmission; Dyspnea; Enzymes; Fever; Gene amplification; Gene polymorphism; Genetic aspects; Genetic diversity; Genetic testing; Genotype & phenotype; Haplotypes; Health aspects; Heterozygosity; Hospital patients; Hospitals; Humans; Hypertension; Infections; Male; Medical research; Medicine, Experimental; Middle Aged; Mortality; Pakistan; Patients; Peptidyl-dipeptidase A; Polymorphism, Single Nucleotide; Polymorphisms; Population; Risk factors; rs2285666; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Single nucleotide polymorphisms; Single-nucleotide polymorphism; SNPs; Statistical analysis; Taste disorders; Variants; Viral infections; Pakistan; rs2285666; SNPs; ACE2; Variants; SARS-CoV-2; Polymorphisms

Science is digging for the varied presentation of COVID-19 patients exposed to the same risk factors, and medical conditions may be influenced by the presence of polymorphic genetic variants. This study investigated the link between ACE2 gene polymorphisms and the severity of SARS-CoV-2. This cross-...