A multi-centre evaluation of eleven clinically feasible brain PET/MRI attenuation correction techniques using a large cohort of patients

• Published in: NeuroImage (Orlando, Fla.) Vol. 147; pp. 346 - 359
• Main Authors: Ladefoged, Claes N., Law, Ian, Anazodo, Udunna, St. Lawrence, Keith, Izquierdo-Garcia, David, Catana, Ciprian, Burgos, Ninon, Cardoso, M. Jorge, Ourselin, Sebastien, Hutton, Brian, Mérida, Inés, Costes, Nicolas, Hammers, Alexander, Benoit, Didier, Holm, Søren, Juttukonda, Meher, An, Hongyu, Cabello, Jorge, Lukas, Mathias, Nekolla, Stephan, Ziegler, Sibylle, Fenchel, Matthias, Jakoby, Bjoern, Casey, Michael E., Benzinger, Tammie, Højgaard, Liselotte, Hansen, Adam E., Andersen, Flemming L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.02.2017; Elsevier Limited; Elsevier
• Subjects: Accuracy; Adult; Aged; Aged, 80 and over; Attenuation correction; Bone density; Bone imaging; Brain; Brain - diagnostic imaging; Cognitive Dysfunction - diagnostic imaging; Cohort Studies; Computed tomography; Computer Science; Data processing; Dementia - diagnostic imaging; Dementia disorders; Female; Glucose; Humans; Image processing; Image Processing, Computer-Assisted - methods; Image Processing, Computer-Assisted - standards; Learning algorithms; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging - standards; Male; Medical Imaging; Methods; Middle Aged; Neuroimaging; Neurological diseases; NMR; Nuclear magnetic resonance; Perfusion; PET/MRI; Positron emission tomography; Positron-Emission Tomography - methods; Positron-Emission Tomography - standards; Radioactive tracers; Radioactivity; Radiopharmaceuticals; Segmentation; Silver; Sinus; Skull; Standardization; Suppressor of Hairless protein; Young Adult; United States > US; Brain; Attenuation correction; PET/MRI; brain

To accurately quantify the radioactivity concentration measured by PET, emission data need to be corrected for photon attenuation; however, the MRI signal cannot easily be converted into attenuation values, making attenuation correction (AC) in PET/MRI challenging. In order to further improve the cu...