Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons - Kraytsberg, Yevgenya; Kudryavtseva, Elena; McKee, Ann C; Geula, Changiz; Kowall, Neil W; Khrapko, Konstantin (Nature genetics, 2006)
Keywords: Aging; Aging - genetics; Agriculture; Animal Genetics and Genomics; Animals; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Brain stem; brief-communication; Cancer Research; Complications and side effects; Cytochrome; Degeneration; DNA damage; DNA, Mitochondrial - genetics; Electron Transport Complex IV - genetics; Fundamental and applied biological sciences. Psychology; Gene Function; Genetic aspects; Genetics of eukaryotes. Biological and molecular evolution; Human Genetics; Human subjects; Mice; Mice, Transgenic; Mitochondrial DNA; Nervous system; Neurons; Neurons - pathology; Parkinson's disease; Physiological aspects; Quantitative genetics; Respiration; Substantia Nigra - pathology; United States; Human; Deletion; Mitochondrial DNA; Neuron; Ageing