Adiponectin deficiency is a critical factor contributing to cognitive dysfunction in obese mice after sevoflurane exposure

• Published in: Molecular medicine (Cambridge, Mass.) Vol. 30; no. 1; pp. 177 - 16
• Main Authors: Chu, John Man Tak, Chiu, Suki Pak Wing, Wang, Jiaqi, Chang, Raymond Chuen Chung, Wong, Gordon Tin Chun
• Format: Journal Article
• Language: English
• Published: England BioMed Central 16.10.2024; BMC
• Subjects: Adiponectin; Adiponectin - metabolism; Anesthesia; Anesthetics, Inhalation - adverse effects; Animal cognition; Animals; Cognitive ability; Cognitive dysfunction; Cognitive Dysfunction - etiology; Disease Models, Animal; Male; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Obese; Neuroinflammation; Neurotoxicity; Obesity; Obesity - complications; Problem solving; Sevoflurane - adverse effects; Sevoflurane-induced neurotoxicity; Software; United States > US; Obesity; Neuroinflammation; Sevoflurane-induced neurotoxicity; Cognitive dysfunction; Adiponectin

The number of major operations performed in obese patients is expected to increase given the growing prevalence of obesity. Obesity is a risk factor for a range of postoperative complications including perioperative neurocognitive disorders. However, the mechanisms underlying this vulnerability are...