More powerful dysregulation of Helicobacter pylori East Asian-type CagA on intracellular signalings

• Published in: BMC microbiology Vol. 24; no. 1; pp. 467 - 15
• Main Authors: Ji, Xiaofei, Sun, Zekun, Wu, Hao, Zhang, Jianhui, Liu, Shuzhen, Cao, Xinying, Wang, Bin, Wang, Feifan, Zhang, Ying, Li, Boqing, Feng, Jiankai, Zhao, Huilin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.11.2024; BioMed Central; BMC
• Subjects: Analysis; Antigens, Bacterial - genetics; Antigens, Bacterial - metabolism; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biotechnology; CagA; Cancer; Carcinogens; Care and treatment; Cell culture; Cell Line; Cell migration; Cell Movement; Cell viability; Chronic infection; Complications and side effects; Diagnosis; E coli; East Asian People; Epithelial cells; Epithelial Cells - microbiology; Epithelium; Gastric cancer; Gastric Mucosa - microbiology; Gastric Mucosa - pathology; Gastrointestinal diseases; Gene expression; Growth factors; Helicobacter infections; Helicobacter Infections - microbiology; Helicobacter pylori; Helicobacter pylori - genetics; Helicobacter pylori - pathogenicity; Humans; Hypoxia; Hypoxia-inducible factor 1a; Infections; Inflammation; Inflammatory response; Interleukin 8; Interleukin-8 - genetics; Interleukin-8 - metabolism; Intracellular; Intracellular signalling; Kinases; Laboratory animals; NF-κB protein; Phenotypes; Plasmids; Reactive oxygen species; Risk factors; Sarcoma; Signal Transduction; Stomach Neoplasms - genetics; Stomach Neoplasms - microbiology; Transcriptome analysis; Transcriptomes; Up-regulation; Virulence (Microbiology); γ-Interferon; China; United Kingdom > UK; United States > US; Hypoxia; Transcriptome analysis; Helicobacter pylori; Gastric cancer; CagA

Chronic infection by Helicobacter pylori strains expressing cytotoxin-associated gene A (CagA) are the strongest risk factor for gastric cancer. CagA can be classified into East Asian-type and Western-type (CagA and CagA ), with CagA being more closely associated with gastric cancer. This study aime...