Role of sodium channel inhibition in neuroprotection: effect of vinpocetine

• Published in: Brain Research Bulletin Vol. 53; no. 3; pp. 245 - 254
• Main Authors: Bönöczk, Péter, Gulyás, Balázs, Adam-Vizi, Vera, Nemes, András, Kárpáti, Egon, Kiss, Béla, Kapás, Margit, Szántay, Csaba, Koncz, István, Zelles, Tibor, Vas, Adam
• Format: Book Review Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.10.2000; Elsevier Science
• Subjects: Animals; Biological and medical sciences; Calcium - metabolism; Calcium Channel Blockers - pharmacology; Cardiovascular system; Cerebrovascular disorders; Cerebrovascular Disorders - prevention & control; Humans; Medical sciences; Medicin och hälsovetenskap; Neuroprotection; Neuroprotective Agents - pharmacology; PET studies; Pharmacology. Drug treatments; Vasodilator agents. Cerebral vasodilators; Vinca Alkaloids - pharmacology; Vinpocetine; Neuroprotection; Cerebrovascular disorders; PET studies; Vinpocetine; Regional blood flow; Vasodilator agent; Sodium; Cardiovascular disease; Ionic channel; Neuroprotective agent; Hemodynamics; Review; Inhibition; Cerebrovascular disease

Vinpocetine (ethyl apovincaminate) discovered during the late 1960s has successfully been used in the treatment of central nervous system disorders of cerebrovascular origin for decades. The increase in the regional cerebral blood flow in response to vinpocetine administration is well established an...