Role of sodium channel inhibition in neuroprotection: effect of vinpocetine
Vinpocetine (ethyl apovincaminate) discovered during the late 1960s has successfully been used in the treatment of central nervous system disorders of cerebrovascular origin for decades. The increase in the regional cerebral blood flow in response to vinpocetine administration is well established an...
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| Published in | Brain Research Bulletin Vol. 53; no. 3; pp. 245 - 254 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Book Review Journal Article |
| Language | English |
| Published |
New York, NY
Elsevier Inc
01.10.2000
Elsevier Science |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Vinpocetine (ethyl apovincaminate) discovered during the late 1960s has successfully been used in the treatment of central nervous system disorders of cerebrovascular origin for decades. The increase in the regional cerebral blood flow in response to vinpocetine administration is well established and strengthened by new diagnostical techniques (transcranial Doppler, near infrared spectroscopy, positron emission tomography). The latest
in vitro studies have revealed the effect of the compound on Ca
2+/calmodulin dependent cyclic guanosine monophosphate-phosphodiesterase 1, voltage–operated Ca
2+ channels, glutamate receptors and voltage dependent Na
+-channels; the latest being especially relevant to the neuroprotective action of vinpocetine. The good brain penetration profile and heterogenous brain distribution pattern (mainly in the thalamus, basal ganglia and visual cortex) of labelled vinpocetin were demonstrated by positron emission tomography in primates and man. Multicentric, randomized, placebo-controlled clinical studies proved the efficacy of orally administered vinpocetin in patients with organic psychosyndrome. Recently positron emission tomography studies have proved that vinpocetine is able to redistribute regional cerebral blood flow and enhance glucose supply of brain tissue in ischemic post-stroke patients. |
|---|---|
| AbstractList | Vinpocetine (ethyl apovincaminate) discovered during the late 1960s has successfully been used in the treatment of central nervous system disorders of cerebrovascular origin for decades. The increase in the regional cerebral blood flow in response to vinpocetine administration is well established and strengthened by new diagnostical techniques (transcranial Doppler, near infrared spectroscopy, positron emission tomography). The latest
in vitro studies have revealed the effect of the compound on Ca
2+/calmodulin dependent cyclic guanosine monophosphate-phosphodiesterase 1, voltage–operated Ca
2+ channels, glutamate receptors and voltage dependent Na
+-channels; the latest being especially relevant to the neuroprotective action of vinpocetine. The good brain penetration profile and heterogenous brain distribution pattern (mainly in the thalamus, basal ganglia and visual cortex) of labelled vinpocetin were demonstrated by positron emission tomography in primates and man. Multicentric, randomized, placebo-controlled clinical studies proved the efficacy of orally administered vinpocetin in patients with organic psychosyndrome. Recently positron emission tomography studies have proved that vinpocetine is able to redistribute regional cerebral blood flow and enhance glucose supply of brain tissue in ischemic post-stroke patients. Vinpocetine (ethyl apovincaminate) discovered during the late 1960s has successfully been used in the treatment of central nervous system disorders of cerebrovascular origin for decades. The increase in the regional cerebral blood flow in response to vinpocetine administration is well established and strengthened by new diagnostical techniques (transcranial Doppler, near infrared spectroscopy, positron emission tomography). The latest in vitro studies have revealed the effect of the compound on Ca(2+)/calmodulin dependent cyclic guanosine monophosphate-phosphodiesterase 1, voltage-operated Ca(2+) channels, glutamate receptors and voltage dependent Na(+)-channels; the latest being especially relevant to the neuroprotective action of vinpocetine. The good brain penetration profile and heterogenous brain distribution pattern (mainly in the thalamus, basal ganglia and visual cortex) of labelled vinpocetin were demonstrated by positron emission tomography in primates and man. Multicentric, randomized, placebo-controlled clinical studies proved the efficacy of orally administered vinpocetin in patients with organic psychosyndrome. Recently positron emission tomography studies have proved that vinpocetine is able to redistribute regional cerebral blood flow and enhance glucose supply of brain tissue in ischemic post-stroke patients. Vinpocetine (ethyl apovincaminate) discovered during the late 1960s has successfully been used in the treatment of central nervous system disorders of cerebrovascular origin for decades. The increase in the regional cerebral blood flow in response to vinpocetine administration is well established and strengthened by new diagnostical techniques (transcranial Doppler, near infrared spectroscopy, positron emission tomography). The latest in vitro studies have revealed the effect of the compound on Ca super(2+)/calmodulin dependent cyclic guanosine monophosphate-phosphodiesterase 1, voltage-operated Ca super(2+) channels, glutamate receptors and voltage dependent Na super(+)-channels; the latest being especially relevant to the neuroprotective action of vinpocetine. The good brain penetration profile and heterogenous brain distribution pattern (mainly in the thalamus, basal ganglia and visual cortex) of labelled vinpocetin were demonstrated by positron emission tomography in primates and man. Multicentric, randomized, placebo-controlled clinical studies proved the efficacy of orally administered vinpocetin in patients with organic psychosyndrome. Recently positron emission tomography studies have proved that vinpocetine is able to redistribute regional cerebral blood flow and enhance glucose supply of brain tissue in ischemic post-stroke patients. |
| Author | Gulyás, Balázs Zelles, Tibor Adam-Vizi, Vera Kapás, Margit Szántay, Csaba Kárpáti, Egon Koncz, István Nemes, András Vas, Adam Bönöczk, Péter Kiss, Béla |
| Author_xml | – sequence: 1 givenname: Péter surname: Bönöczk fullname: Bönöczk, Péter organization: Chemical Works of Gedeon Richter Ltd., Budapest, Hungary – sequence: 2 givenname: Balázs surname: Gulyás fullname: Gulyás, Balázs organization: Department of Neuroscience, Karolinska Institute, Stockholm, Sweden – sequence: 3 givenname: Vera surname: Adam-Vizi fullname: Adam-Vizi, Vera organization: Department of Medical Biochemistry, Semmelweis University, Budapest, Hungary – sequence: 4 givenname: András surname: Nemes fullname: Nemes, András organization: Chemical Works of Gedeon Richter Ltd., Budapest, Hungary – sequence: 5 givenname: Egon surname: Kárpáti fullname: Kárpáti, Egon organization: Chemical Works of Gedeon Richter Ltd., Budapest, Hungary – sequence: 6 givenname: Béla surname: Kiss fullname: Kiss, Béla organization: Chemical Works of Gedeon Richter Ltd., Budapest, Hungary – sequence: 7 givenname: Margit surname: Kapás fullname: Kapás, Margit organization: Chemical Works of Gedeon Richter Ltd., Budapest, Hungary – sequence: 8 givenname: Csaba surname: Szántay fullname: Szántay, Csaba organization: Department of Organic Chemistry, Technical University, Budapest, Hungary – sequence: 9 givenname: István surname: Koncz fullname: Koncz, István organization: Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary – sequence: 10 givenname: Tibor surname: Zelles fullname: Zelles, Tibor organization: Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary – sequence: 11 givenname: Adam surname: Vas fullname: Vas, Adam email: a.vas@richter.hu organization: Chemical Works of Gedeon Richter Ltd., Budapest, Hungary |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=846675$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/11113577$$D View this record in MEDLINE/PubMed http://kipublications.ki.se/Default.aspx?queryparsed=id:13078510$$DView record from Swedish Publication Index |
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| Keywords | Neuroprotection Cerebrovascular disorders PET studies Vinpocetine Regional blood flow Vasodilator agent Sodium Cardiovascular disease Ionic channel Neuroprotective agent Hemodynamics Review Inhibition Cerebrovascular disease |
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| SubjectTerms | Animals Biological and medical sciences Calcium - metabolism Calcium Channel Blockers - pharmacology Cardiovascular system Cerebrovascular disorders Cerebrovascular Disorders - prevention & control Humans Medical sciences Medicin och hälsovetenskap Neuroprotection Neuroprotective Agents - pharmacology PET studies Pharmacology. Drug treatments Vasodilator agents. Cerebral vasodilators Vinca Alkaloids - pharmacology Vinpocetine |
| Title | Role of sodium channel inhibition in neuroprotection: effect of vinpocetine |
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