Vitamin a potentiates sheep myoblasts myogenic differentiation through BHLHE40-modulated ID3 expression

• Published in: BMC genomics Vol. 25; no. 1; pp. 244 - 12
• Main Authors: Song, Pengkang, Zhao, Jiamin, Zhang, Weipeng, Li, Xuying, Ji, Bingzhen, Zhao, Junxing
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.03.2024; BioMed Central; BMC
• Subjects: Analysis; Animals; BHLHE40; Cell growth; Differentiation; DNA binding inhibitor 3; Dosage and administration; Fetuses; Gene expression; Gene sequencing; Genes; Injections, Intramuscular; Lamb; Medical examination; Metabolites; Muscle Development; Muscles; Musculoskeletal system; Mutton; Myoblast; Myoblasts; Myogenesis; Online data bases; Paraspinal Muscles; Principal components analysis; Retinene; Retinoic acid; Ribonucleic acid; RNA; RNA sequencing; Sheep; Skeletal muscle; Transcriptomes; Tretinoin; Tretinoin - pharmacology; Vitamin A; Vitamin A - pharmacology; China; Germany; Myoblast; Vitamin A; Lamb; BHLHE40; DNA binding inhibitor 3

Vitamin A and retinoic acid (RA, a metabolite of vitamin A), are inextricably involved to the development of skeletal muscle in animals. However, the mechanisms regulating skeletal muscle development by vitamin A remain poorly reported. The current study designed to investigate the underlying mechan...