High-fat diet in early life triggers both reversible and persistent epigenetic changes in the medaka fish (Oryzias latipes) - Inoue, Yusuke; Suzuki, Yuta; Kunishima, Yoshimi; Washio, Terumi; Morishita, Shinichi; Takeda, Hiroyuki (BMC genomics, 2023)
Keywords: Analysis; Animals; Cell signaling; Chromatin; Chromatin accessibility; Developmental stages; Diabetes; Diet; Diet, High-Fat; DNA methylation; Epigenesis, Genetic; Epigenetic inheritance; Epigenetics; Fatty liver; Fertilization; Fetuses; Fibrosis; Gastrointestinal surgery; Gene expression; Gene Expression Regulation, Developmental; Genes; Genetic Loci; Genomes; Genomics; Hatching; Health aspects; Hepatocellular carcinoma; Hepatocytes; High fat diet; Histone modifications; Histones; Larvae; Lipids; Liver; Liver cancer; Liver diseases; Long-term effects; Mammals; Medaka; Metabolism; Nutrients; Nutrition; Nutritional programming; Nutritional status; Oryzias - genetics; Oryzias - growth & development; Physiological aspects; Steatosis; Transcriptomes; Transcriptomics; Type 2 diabetes; Vertebrates; Japan; Medaka; Chromatin accessibility; Histone modifications; Fatty liver; Nutritional programming; High-fat diet