Imaging the metabolic reprograming of fatty acid synthesis pathway enables new diagnostic and therapeutic opportunity for breast cancer

• Published in: Cancer cell international Vol. 23; no. 1; pp. 83 - 11
• Main Authors: Wang, Fukai, Ma, Shuangshuang, Chen, Panpan, Han, Yuhao, Liu, Zhaoyun, Wang, Xinzhao, Sun, Chenglong, Yu, Zhiyong
• Format: Journal Article
• Language: English
• Published: England BioMed Central 29.04.2023; BMC
• Subjects: Antibodies; Breast cancer; Cell proliferation; Cells; Diagnosis and therapy; Enzymes; Fatty acid synthesis pathway; Fatty acids; Fatty-acid synthase; Glucose; Immunofluorescence; Ions; Mass spectrometry; Mass spectrometry imaging; Mass spectroscopy; Metabolic networks; Metabolic reprograming; Metabolism; Metabolites; Metastases; Metastasis; Scientific imaging; Signal transduction; Tissues; Fatty acid synthesis pathway; Breast cancer; Metabolic reprograming; Diagnosis and therapy; Mass spectrometry imaging

Reprogrammed metabolic network is a key hallmark of cancer. Profiling cancer metabolic alterations with spatial signatures not only provides clues for understanding cancer biochemical heterogeneity, but also helps to decipher the possible roles of metabolic reprogramming in cancer development. Matri...