Stochasticity in gene expression: from theories to phenotypes

• Published in: Nature reviews. Genetics Vol. 6; no. 6; pp. 451 - 464
• Main Authors: Kærn, Mads, Elston, Timothy C., Blake, William J., Collins, James J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2005; Nature Publishing Group
• Subjects: Agriculture; Animal Genetics and Genomics; Animals; Bacteria - genetics; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Eukaryotic Cells - metabolism; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression - physiology; Gene Expression Regulation; Gene Function; Genetics of eukaryotes. Biological and molecular evolution; Human Genetics; Kinetics; Phenotype; Proteins; Ratios; review-article; Simulation; Stochastic models; Stochastic Processes; United States > US; Gene expression; Phenotype

Key Points Stochasticity in gene expression is manifested as fluctuations in the abundance of expressed molecules at the single-cell level, and variability and heterogeneity within populations of genetically identical cells. Analyses of simple models indicate that stochasticity in gene expression is...