Integrating host transcriptomic signatures for distinguishing autoimmune encephalitis in cerebrospinal fluid by metagenomic sequencing

• Published in: Cell & bioscience Vol. 13; no. 1; pp. 111 - 15
• Main Authors: Fan, Siyuan, He, Xiangyan, Zhu, Zhongyi, Chen, Lu, Zou, Yijun, Chen, Zhonglin, Yu, Jialin, Chen, Weijun, Guan, Hongzhi, Ma, Jinmin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.06.2023; BioMed Central; BMC
• Subjects: Antigen presentation; Antigen processing; Antigens; Autoimmune diseases; Autoimmune encephalitis; Biomarkers; Care and treatment; Cerebrospinal fluid; Comparative analysis; Degranulation; Encephalitis; Gene expression; Genes; Immune response; Infections; Infectious encephalitis; Leukocytes (neutrophilic); Metagenomics; Neutrophils; Next-generation sequencing; Next-generation sequencing (NGS); Pathogens; Patients; Proteins; Sense organs; Signal transduction; Synaptic transmission; Transcriptomic signatures; Transcriptomics; Transcriptomic signatures; Infectious encephalitis; Cerebrospinal fluid; Next-generation sequencing (NGS); Autoimmune encephalitis

The early accurate diagnoses for autoimmune encephalitis (AE) and infectious encephalitis (IE) are essential since the treatments for them are different. This study aims to discover some specific and sensitive biomarkers to distinguish AE from IE at early stage to give specific treatments for good o...