Metabolic reprogramming and immune evasion: the interplay in the tumor microenvironment

• Published in: Biomarker research Vol. 12; no. 1; pp. 96 - 25
• Main Authors: Zhang, Haixia, Li, Shizhen, Wang, Dan, Liu, Siyang, Xiao, Tengfei, Gu, Wangning, Yang, Hongmin, Wang, Hui, Yang, Minghua, Chen, Pan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.09.2024; BioMed Central; BMC
• Subjects: Amino acid sequence; Amino acids; Antigens; Apoptosis; B cells; Breast cancer; Cancer; Cancer immunotherapy; Cell differentiation; Cells; Chemokines; Colorectal cancer; Competition; Cytotoxicity; Development and progression; Dextrose; Effector cells; Enzymes; Genotype & phenotype; Glucose; Glucose metabolism; Hypoxia; Immune evasion; Immune response; Immune system; Immunogenicity; Immunoregulation; Immunotherapy; Kinases; Ligands; Lipid metabolism; Liver cancer; Lymphocytes T; Metabolic pathways; Metabolic reprogramming; Metabolism; Metabolites; Metastasis; Mutation; Physiological aspects; Proteins; Review; Suppressor cells; T cells; Tumor cells; Tumor microenvironment; Tumors; Immune evasion; Metabolic reprogramming; Tumor microenvironment; Immunotherapy

Tumor cells possess complex immune evasion mechanisms to evade immune system attacks, primarily through metabolic reprogramming, which significantly alters the tumor microenvironment (TME) to modulate immune cell functions. When a tumor is sufficiently immunogenic, it can activate cytotoxic T-cells...