Unveiling the fructose metabolism system in Staphylococcus aureus: insights into the regulatory role of FruR and the FruRKT operon in bacterial fitness

• Published in: BMC microbiology Vol. 24; no. 1; pp. 13 - 12
• Main Authors: Ge, Yan, Li, Daiyu, Wang, Ning, Shi, Yun, Guo, Gang, Fang, Liyuan, Zou, Quanming, Liu, Qiang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.01.2024; BioMed Central; BMC
• Subjects: Analysis; Bacteria; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Base Sequence; Binding; Carbon; Carbon sources; Chromosomes; DeoR; Fructose; Fructose - metabolism; Fructose phosphotransferase; Gene Expression Regulation, Bacterial; Genes; Genetic aspects; Genetic transcription; Genomes; Health aspects; Intracellular; Metabolism; Microorganisms; Operon; Pathogenicity; Pathogens; Phosphates; Phosphotransferase; Phosphotransferases - genetics; Proteins; Regulatory mechanisms (biology); RNA; RNA polymerase; S. Aureus; Staphylococcus aureus; Staphylococcus aureus - genetics; Staphylococcus aureus - metabolism; Transcription factors; Transcriptional regulator; Utilization; Virulence; Virulence (Microbiology); China; Transcriptional regulator; Fructose metabolism; DeoR; S. Aureus

The utilization of fructose as a carbon source and energy provider plays a crucial role in bacterial metabolism. Additionally, fructose metabolism directly impacts the pathogenicity and virulence of certain pathogenic microorganisms. In this study, we report the discovery of a fructose phosphotransf...