A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex

• Published in: Human molecular genetics Vol. 17; no. 19; pp. 3030 - 3042
• Main Authors: Mellios, Nikolaos, Huang, Hsien-Sung, Grigorenko, Anastasia, Rogaev, Evgeny, Akbarian, Schahram
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.10.2008; Oxford Publishing Limited (England)
• Subjects: 3' Untranslated Regions - genetics; Adolescent; Adult; Aged; Base Sequence; Biological and medical sciences; Brain-Derived Neurotrophic Factor - genetics; Brain-Derived Neurotrophic Factor - metabolism; Child; Child, Preschool; Classical genetics, quantitative genetics, hybrids; Down-Regulation; Female; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation, Developmental; Genetics of eukaryotes. Biological and molecular evolution; Humans; Infant; Male; Methods, theories and miscellaneous; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; Molecular and cellular biology; Molecular genetics; Neurons - metabolism; Prefrontal Cortex - growth & development; Prefrontal Cortex - metabolism; Pregnancy; Transcription, Genetic; Transcription. Transcription factor. Splicing. Rna processing; Genetic mapping; Gene silencing; RNA interference; Transcription; Micro RNA; Genetics; Inhibitor; Gene expression

Expression of brain-derived neurotrophic factor (BDNF) is developmentally regulated in prefrontal cortex (PFC). The underlying molecular mechanisms, however, remain unclear. Here, we explore the role of microRNAs (miRNAs) as post-transcriptional inhibitors of BDNF. A sequential approach involving in...