IL28B Gene Polymorphism SNP rs8099917 Genotype GG Is Associated with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in HTLV-1 Carriers

• Published in: PLoS neglected tropical diseases Vol. 8; no. 9; p. e3199
• Main Authors: Assone, Tatiane, Souza, Fernando Vieira de, Gaester, Karen Oliveira, Fonseca, Luiz Augusto Marcondes, Luiz, Olinda do Carmo, Malta, Fernanda, Pinho, João Renato Rebello, Gonçalves, Fernanda de Toledo, Duarte, Alberto Jose da Silva, de Oliveira, Augusto Cesar Penalva, Casseb, Jorge
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.09.2014; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Biology and Life Sciences; Cytokines; Deoxyribonucleic acid; Development and progression; Disease; DNA; Female; Genes; Genetic aspects; Genotype; Genotype & phenotype; HTLV-I Infections - complications; HTLV-I Infections - virology; Human T-lymphotropic virus 1; Humans; Infections; Interferons; Interleukins; Interleukins - genetics; Male; Medicine and Health Sciences; Middle Aged; Paraparesis, Tropical spastic; Paraparesis, Tropical Spastic - genetics; Pathogenesis; Polymerase Chain Reaction; Polymorphism, Single Nucleotide - genetics; Properties; Proviruses - genetics; Real-Time Polymerase Chain Reaction; Single nucleotide polymorphisms; Viral infections; Viral Load

The polymorphisms of IL28B have been described as important in the pathogenesis of infections caused by some viruses. The aim of this research was to evaluate whether IL28B gene polymorphisms (SNP rs8099917 and SNP rs12979860) are associated with HAM/TSP. The study included 229 subjects, classified...