Gut microbiota-derived LCA mediates the protective effect of PEDV infection in piglets

• Published in: Microbiome Vol. 12; no. 1; pp. 20 - 25
• Main Authors: Xing, Jun-Hong, Niu, Tian-Ming, Zou, Bo-Shi, Yang, Gui-Lian, Shi, Chun-Wei, Yan, Qing-Song, Sun, Ming-Jie, Yu, Tong, Zhang, Shu-Min, Feng, Xi-Ze, Fan, Shu-Hui, Huang, Hai-Bin, Wang, Jun-Hong, Li, Ming-Han, Jiang, Yan-Long, Wang, Jian-Zhong, Cao, Xin, Wang, Nan, Zeng, Yan, Hu, Jing-Tao, Zhang, Di, Sun, Wu-Sheng, Yang, Wen-Tao, Wang, Chun-Feng
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.02.2024; BioMed Central; BMC
• Subjects: Acids; Animal models; Animals; Antibiotics; Antiviral agents; Antiviral drugs; Bacteria; Bile; Bile acids; CD8 antigen; Coronavirus Infections - prevention & control; Coronavirus Infections - veterinary; Deoxycholic acid; Development and progression; Diarrhea; Digestive system; Disease; Disease Resistance; Epithelial cells; Experiments; Fecal microflora; Feces; Gastrointestinal Microbiome; Gastrointestinal tract; Glycerol; Gut microbiota; Hogs; Immune system; Infection; Infection resistance; Infections; Intestinal microflora; Intestine; Lactobacillus amylovorus; Lactobacillus reuteri; Lymphocytes T; Macrogenomic; Metabolites; Metabolomic; Metabolomics; Metagenomics; Methylene blue; Microbiota; Microbiota (Symbiotic organisms); Neomycin; Pathogens; Porcine epidemic diarrhea virus; Signal transduction; Swine; Swine Diseases - prevention & control; T cell response; T cells; Transcriptomics; Transmissible gastroenteritis; Wildlife conservation; China; Germany; United States > US; Gut microbiota; Metabolomic; Macrogenomic; Infection resistance; T cell response

The gut microbiota is a critical factor in the regulation of host health, but the relationship between the differential resistance of hosts to pathogens and the interaction of gut microbes is not yet clear. Herein, we investigated the potential correlation between the gut microbiota of piglets and t...