IMP1 regulates UCA1-mediated cell invasion through facilitating UCA1 decay and decreasing the sponge effect of UCA1 for miR-122-5p

• Published in: Breast cancer research : BCR Vol. 20; no. 1; pp. 32 - 15
• Main Authors: Zhou, Yanchun, Meng, Xiuhua, Chen, Shaoying, Li, Wei, Li, Delin, Singer, Robert, Gu, Wei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18.04.2018; BioMed Central; BMC
• Subjects: Analysis; Binding proteins; Breast Neoplasms - genetics; Cell Line, Tumor; Cell Movement - genetics; Cell Proliferation - genetics; Epithelial-Mesenchymal Transition - genetics; Female; Gene Expression Regulation, Neoplastic; Humans; IMP1; IMP1-UCA1 interaction; Insulin-like growth factor I; lncRNA; MicroRNA; MicroRNAs - genetics; Neoplasm Invasiveness - genetics; Neoplasm Invasiveness - pathology; RNA sequencing; RNA, Long Noncoding - genetics; RNA-binding protein; RNA-Binding Proteins - genetics; UCA1; UCA1-miR122-5p interaction; IMP1-UCA1 interaction; UCA1; RNA-binding protein; lncRNA; UCA1-miR122-5p interaction; IMP1

Long noncoding RNAs (LncRNAs) represent a class of widespread and diverse endogenous RNAs that can posttranscriptionally regulate gene expression through the interaction with RNA-binding proteins and micro RNAs (miRNAs). Here, we report that in breast carcinoma cells, the insulin-like growth factor...