The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells

• Published in: Breast cancer research : BCR Vol. 20; no. 1; pp. 16 - 15
• Main Authors: Kim, Hoon, Lin, Qun, Glazer, Peter M., Yun, Zhong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.03.2018; BioMed Central; BMC
• Subjects: AKT; Animals; Breast cancer; Breast cancer cell; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Cancer stem cell; Cell Differentiation - genetics; Cell fate; Cell Lineage - genetics; Development and progression; Female; Humans; Hypoxia; MCF-7 Cells; Mice; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; PI3K; Prognosis; Stem cells; Tumor Hypoxia - genetics; Tumor Microenvironment - genetics; Tumors; Xenograft Model Antitumor Assays; Xenotransplantation; Xenograft; Cell fate; PI3K; Tumor microenvironment; Cancer stem cell; Breast cancer cell; Hypoxia; AKT

Tumor hypoxia is an independent prognostic factor associated with poor patient survival. Emerging evidence suggests that hypoxia can potentially maintain or enhance the stem cell phenotype of both normal stem cells and cancer cells. However, it remains to be determined whether cell fate is regulated...