Exosomal miR-125b-5p derived from adipose-derived mesenchymal stem cells enhance diabetic hindlimb ischemia repair via targeting alkaline ceramidase 2

• Published in: Journal of nanobiotechnology Vol. 21; no. 1; pp. 189 - 18
• Main Authors: Guo, Jiahe, Yang, Xiaofan, Chen, Jing, Wang, Cheng, Sun, Yue, Yan, Chengqi, Ren, Sen, Xiong, Hewei, Xiang, Kaituo, Zhang, Maojie, Li, Chengcheng, Jiang, Guoyong, Xiang, Xuejiao, Wan, Gui, Jiang, Tao, Kang, Yu, Xu, Xiang, Chen, Zhenbing, Li, Wenqing
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 12.06.2023; BioMed Central; BMC
• Subjects: Adipose-derived mesenchymal stem cells; Alkaline Ceramidase; Alkaline ceramidase 2; Amputation; Analysis; Angiogenesis; Animals; Bioinformatics; Bioinformatics analysis; Care and treatment; Cell culture; Cell migration; Cell proliferation; Ceramidase; Complications and side effects; Computational biology; Diabetes; Diabetes Mellitus; Diabetes therapy; Diagnosis; Doppler effect; Exosomes; Hindlimb; Hindlimb ischemia; Hypoxia; Injuries; Injury analysis; Ischemia; Limbs; Mesenchymal Stem Cells; MicroRNA; MicroRNAs; miR-125b-5p; miRNA; Morphology; Muscles; Sequences; Skeletal muscle; Stem cells; Ultracentrifugation; Wound healing; China; Bioinformatics analysis; miR-125b-5p; Adipose-derived mesenchymal stem cells; Alkaline ceramidase 2; Hindlimb ischemia; Exosomes

Ischemic diseases caused by diabetes continue to pose a major health challenge and effective treatments are in high demand. Mesenchymal stem cells (MSCs) derived exosomes have aroused broad attention as a cell-free treatment for ischemic diseases. However, the efficacy of exosomes from adipose-deriv...