Extracorporeal shockwave therapy (ESWT) – First choice treatment of fracture non-unions?
Fracture non-unions are still a challenging problem in orthopedics. The treatment of non-unions remains highly individualized, complex, and demanding. In most countries the surgical approach with debridement of the non-union gap, anatomical reduction and appropriate osteosynthesis along with autolog...
Saved in:
| Published in | International journal of surgery (London, England) Vol. 24; no. Pt B; pp. 179 - 183 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.12.2015
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1743-9191 1743-9159 |
| DOI | 10.1016/j.ijsu.2015.10.003 |
Cover
Loading…
| Abstract | Fracture non-unions are still a challenging problem in orthopedics. The treatment of non-unions remains highly individualized, complex, and demanding. In most countries the surgical approach with debridement of the non-union gap, anatomical reduction and appropriate osteosynthesis along with autologous bone grafting is considered as the standard of care. One of the very first non-urologic applications of extracorporeal shockwave treatment (ESWT) concerned non-healing fractures. Since the early 1990ties the knowledge of the working mechanism has increased enormously. The purpose of this review article is to demonstrate by peer-reviewed literature in conjunction with our own experiences that ESWT can be an efficient, non-invasive, almost complication-free and cost effective alternative to surgical treatment of non-healing fractures.
•Non-healing fractures (pseudarthroses, non-unions) still are a challenging problem in orthopedics.•ESWT is a non-invasive procedure that achieves comparable results to surgical approaches.•Complications associated with ESWT are on rare occasions and minimal if present.•Peer-reviewed literature shows excellent results with medium/high energy focused ESWT, with faster return to competition and athletic activity. |
|---|---|
| AbstractList | Fracture non-unions are still a challenging problem in orthopedics. The treatment of non-unions remains highly individualized, complex, and demanding. In most countries the surgical approach with debridement of the non-union gap, anatomical reduction and appropriate osteosynthesis along with autologous bone grafting is considered as the standard of care. One of the very first non-urologic applications of extracorporeal shockwave treatment (ESWT) concerned non-healing fractures. Since the early 1990ties the knowledge of the working mechanism has increased enormously. The purpose of this review article is to demonstrate by peer-reviewed literature in conjunction with our own experiences that ESWT can be an efficient, non-invasive, almost complication-free and cost effective alternative to surgical treatment of non-healing fractures.
•Non-healing fractures (pseudarthroses, non-unions) still are a challenging problem in orthopedics.•ESWT is a non-invasive procedure that achieves comparable results to surgical approaches.•Complications associated with ESWT are on rare occasions and minimal if present.•Peer-reviewed literature shows excellent results with medium/high energy focused ESWT, with faster return to competition and athletic activity. Abstract Fracture non-unions are still a challenging problem in orthopedics. The treatment of non-unions remains highly individualized, complex, and demanding. In most countries the surgical approach with debridement of the non-union gap, anatomical reduction and appropriate osteosynthesis along with autologous bone grafting is considered as the standard of care. One of the very first non-urologic applications of extracorporeal shockwave treatment (ESWT) concerned non-healing fractures. Since the early 1990ties the knowledge of the working mechanism has increased enormously. The purpose of this review article is to demonstrate by peer-reviewed literature in conjunction with our own experiences that ESWT can be an efficient, non-invasive, almost complication-free and cost effective alternative to surgical treatment of non-healing fractures. Fracture non-unions are still a challenging problem in orthopedics. The treatment of non-unions remains highly individualized, complex, and demanding. In most countries the surgical approach with debridement of the non-union gap, anatomical reduction and appropriate osteosynthesis along with autologous bone grafting is considered as the standard of care. One of the very first non-urologic applications of extracorporeal shockwave treatment (ESWT) concerned non-healing fractures. Since the early 1990ties the knowledge of the working mechanism has increased enormously. The purpose of this review article is to demonstrate by peer-reviewed literature in conjunction with our own experiences that ESWT can be an efficient, non-invasive, almost complication-free and cost effective alternative to surgical treatment of non-healing fractures. |
| Author | Wang, Ching-Jen Haffner, Nicolas Mittermayr, Rainer Gerdesmeyer, Ludger Smolen, Daniel Schaden, Wolfgang |
| Author_xml | – sequence: 1 givenname: Wolfgang surname: Schaden fullname: Schaden, Wolfgang organization: AUVA Trauma Center Meidling, Vienna, Austria – sequence: 2 givenname: Rainer surname: Mittermayr fullname: Mittermayr, Rainer email: Rainer.Mittermayr@trauma.lbg.ac.at organization: AUVA Trauma Center Meidling, Vienna, Austria – sequence: 3 givenname: Nicolas orcidid: 0000-0003-2138-7104 surname: Haffner fullname: Haffner, Nicolas organization: Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Austrian Cluster for Tissue Regeneration, Vienna, Austria – sequence: 4 givenname: Daniel surname: Smolen fullname: Smolen, Daniel organization: Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Austrian Cluster for Tissue Regeneration, Vienna, Austria – sequence: 5 givenname: Ludger surname: Gerdesmeyer fullname: Gerdesmeyer, Ludger organization: Department of Orthopedic Surgery and Traumatology, University Schleswig Holstein, Germany – sequence: 6 givenname: Ching-Jen surname: Wang fullname: Wang, Ching-Jen organization: Center for Shockwave Medicine and Tissue Engineering, Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26454164$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFks9u1DAQxi1URP_AC3BAOZZDFjuxkxghEKq2gFSJQ4uQuFjOZKJ1mrW3ttN2b7wDb8iT4GhbDpUoJ1vj7_vG89Mckj3rLBLyktEFo6x6MyzMEKZFQZlIhQWl5RNywGpe5pIJuff3Ltk-OQxhoJTThjXPyH5RccFZxQ_Ij-Vt9Bqc3ziPeszCysHljb7GLK7Q6802O16ef794nf3--Ss7NT7EDFbOQHpP-rhGGzPXZ33KiJPHLH0xn6xxNnx4Tp72egz44u48It9Olxcnn_Ozr5--nHw8y0HIJuaiK8seZdNDU7XIQNZcl7TRsqsLimUJnYS-bynXhWg70UKtCylR8JYJCm1bHpHjXe7Gu6sJQ1RrEwDHUVt0U1CsFiXnnDGRpK_upFO7xk5tvFlrv1X3PJKg2QnAuxA89gpM1DHNkyiZUTGqZvRqUDN6NaOfawl9shYPrPfpj5re7UyYAF0b9CqAQQvYGY8QVefM4_b3D-wwGmtAj5e4xTC4yduEXjEVCkXV-bwQ8z4kcqyo6nnet_8O-F_3P1g2xuw |
| CitedBy_id | crossref_primary_10_1016_j_jts_2021_02_003 crossref_primary_10_29254_2077_4214_2018_2_144_310_315 crossref_primary_10_1007_s12634_019_0087_7 crossref_primary_10_1038_s41598_017_14875_y crossref_primary_10_1111_jocd_13235 crossref_primary_10_1097_MD9_0000000000000028 crossref_primary_10_1155_2020_1907821 crossref_primary_10_1186_s10195_021_00620_9 crossref_primary_10_1007_s00113_022_01225_5 crossref_primary_10_1186_s13018_017_0667_z crossref_primary_10_1097_SCS_0000000000006506 crossref_primary_10_12998_wjcc_v9_i35_11007 crossref_primary_10_1038_s41443_019_0142_y crossref_primary_10_2106_JBJS_17_00661 crossref_primary_10_3389_fendo_2023_1286480 crossref_primary_10_1515_iss_2016_0021 crossref_primary_10_1155_2016_3850461 crossref_primary_10_1096_fj_202401142RR crossref_primary_10_1016_j_ijso_2017_09_002 crossref_primary_10_1007_s00113_020_00851_1 crossref_primary_10_1242_bio_033258 crossref_primary_10_12998_wjcc_v9_i27_8242 crossref_primary_10_3233_BMR_181289 crossref_primary_10_1016_j_expneurol_2020_113251 crossref_primary_10_1016_j_tcr_2022_100642 crossref_primary_10_1097_JS9_0000000000001280 crossref_primary_10_1093_eurheartj_ehae341 crossref_primary_10_1007_s00132_024_04475_w crossref_primary_10_1016_j_asjsur_2025_01_020 crossref_primary_10_28957_rcmfr_v27n2a6 crossref_primary_10_3390_jcm11071988 crossref_primary_10_1007_s12631_019_0171_x crossref_primary_10_1016_j_bone_2018_09_008 crossref_primary_10_25040_aml2018_01_050 crossref_primary_10_29254_2077_4214_2019_4_1_153_214_217 crossref_primary_10_1097_PRS_0000000000004980 crossref_primary_10_26693_jmbs04_06_009 crossref_primary_10_7759_cureus_37704 crossref_primary_10_1097_BOT_0000000000001361 crossref_primary_10_1007_s00264_020_04778_5 crossref_primary_10_1016_j_injury_2016_04_010 crossref_primary_10_1007_s00068_021_01782_1 crossref_primary_10_11603_2311_9624_2020_2_11257 crossref_primary_10_1016_j_ijsu_2015_12_060 crossref_primary_10_1089_scd_2019_0202 crossref_primary_10_1016_j_bbrc_2020_07_084 crossref_primary_10_29254_2077_4214_2018_1_1_142_204_208 crossref_primary_10_1097_CORR_0000000000001056 crossref_primary_10_1186_s13063_022_06161_8 |
| Cites_doi | 10.2106/JBJS.I.01649 10.1007/s00402-008-0663-1 10.1097/00003086-200106000-00013 10.1007/s00264-008-0553-8 10.1097/00003086-200106000-00014 10.1359/JBMR.040121 10.1016/j.niox.2009.02.006 10.1016/S0736-0266(03)00104-9 10.1159/000128279 10.1016/j.ultrasmedbio.2010.05.004 10.1007/BF00192289 10.1016/j.bone.2003.11.013 10.1152/ajpcell.00342.2009 10.1007/s00402-006-0236-0 10.1096/fj.05-5424rev 10.1007/s001130050492 10.1097/BOT.0b013e3181b26470 10.1016/j.molmed.2013.05.005 10.1097/BOT.0b013e3181cad510 10.1074/jbc.M112.349811 10.1016/j.ijcard.2013.07.112 10.1074/jbc.M308013200 10.1002/stem.1356 10.1097/00003086-200106000-00012 10.2106/JBJS.I.00653 10.2106/JBJS.H.00841 10.1097/00005373-199911000-00024 10.1074/jbc.M114.580936 10.1097/01.jsm.0000393479.96218.d7 |
| ContentType | Journal Article |
| Copyright | 2015 IJS Publishing Group Limited IJS Publishing Group Limited Copyright © 2015 IJS Publishing Group Limited. Published by Elsevier Ltd. All rights reserved. |
| Copyright_xml | – notice: 2015 IJS Publishing Group Limited – notice: IJS Publishing Group Limited – notice: Copyright © 2015 IJS Publishing Group Limited. Published by Elsevier Ltd. All rights reserved. |
| DBID | 6I. AAFTH AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.ijsu.2015.10.003 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 1743-9159 |
| EndPage | 183 |
| ExternalDocumentID | 26454164 10_1016_j_ijsu_2015_10_003 S1743919115012674 1_s2_0_S1743919115012674 |
| Genre | Journal Article Review |
| GroupedDBID | --- --K --M .1- .FO .~1 0R~ 1B1 1P~ 1~. 1~5 4.4 457 4G. 53G 5GY 5VS 7-5 71M 8P~ AAAAV AABNK AAEDT AAEDW AAHPQ AAIKJ AAIQE AAKOC AALRI AAOAW AAQFI AASCR AAWTL AAXUO AAYWO ABASU ABBQC ABDIG ABJNI ABMAC ABMZM ABVCZ ABWVN ABXDB ABZZY ACDAQ ACGFS ACILI ACRLP ACRPL ACVFH ACXJB ADBBV ADCNI ADEZE ADGGA ADHPY ADMUD ADNMO ADPDF ADVLN AEBSH AEIPS AEKER AENEX AEUPX AEVXI AFBFQ AFDTB AFPUW AFRHN AFTJW AGHFR AGUBO AGYEJ AHQNM AIEXJ AIGII AIKHN AINUH AITUG AJCLO AJNWD AJRQY AJUYK AJZMW AKBMS AKCTQ AKRWK AKYEP ALKUP ALMA_UNASSIGNED_HOLDINGS AMJPA AMKUR AMNEI AMRAJ ANKPU ANZVX AOHHW AOQMC AXJTR BKOJK BLXMC CS3 DIWNM EBS EEVPB EFJIC EJD EO8 EO9 EP2 EP3 F5P FCALG FDB FEDTE FIRID FNPLU G-Q GBLVA GNXGY GQDEL HLJTE HVGLF HX~ HZ~ IHE IKREB IXB J1W KOM M41 MO0 N9A O-L O9- OAUVE OK- OK1 OVD OVDNE OW- OZT P-8 P-9 P2P PC. Q38 ROL RPZ SDF SDG SEL SES SPCBC SSZ T5K TEORI TSPGW Z5R ~G- 0SF AACTN AFCTW AFKWA AFXIZ AJOXV AMFUW BNPGV GROUPED_DOAJ NCXOZ RIG SSH 6I. AAFTH AAIAV ABLVK ABVKL ABYKQ AJBFU EFLBG LCYCR AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c598t-5d33fe98fc86be1c974a308a9d720e33cd9cffb04a25bd5bc7a299e54b150cbb3 |
| IEDL.DBID | IXB |
| ISSN | 1743-9191 |
| IngestDate | Thu Jul 10 19:08:03 EDT 2025 Thu Apr 03 07:05:20 EDT 2025 Tue Jul 01 01:03:17 EDT 2025 Thu Apr 24 22:52:11 EDT 2025 Fri Feb 23 02:30:10 EST 2024 Sun Feb 23 10:18:58 EST 2025 Tue Aug 26 16:54:03 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | Pt B |
| Keywords | Non-healing fractures ESWT Pseudarthroses Non-union Extracorporeal shockwave therapy |
| Language | English |
| License | Copyright © 2015 IJS Publishing Group Limited. Published by Elsevier Ltd. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c598t-5d33fe98fc86be1c974a308a9d720e33cd9cffb04a25bd5bc7a299e54b150cbb3 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ORCID | 0000-0003-2138-7104 |
| OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S1743919115012674 |
| PMID | 26454164 |
| PQID | 1753444115 |
| PQPubID | 23479 |
| PageCount | 5 |
| ParticipantIDs | proquest_miscellaneous_1753444115 pubmed_primary_26454164 crossref_citationtrail_10_1016_j_ijsu_2015_10_003 crossref_primary_10_1016_j_ijsu_2015_10_003 elsevier_sciencedirect_doi_10_1016_j_ijsu_2015_10_003 elsevier_clinicalkeyesjournals_1_s2_0_S1743919115012674 elsevier_clinicalkey_doi_10_1016_j_ijsu_2015_10_003 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2015-12-01 |
| PublicationDateYYYYMMDD | 2015-12-01 |
| PublicationDate_xml | – month: 12 year: 2015 text: 2015-12-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | International journal of surgery (London, England) |
| PublicationTitleAlternate | Int J Surg |
| PublicationYear | 2015 |
| Publisher | Elsevier Ltd |
| Publisher_xml | – name: Elsevier Ltd |
| References | Valchanou, Michailov (bib2) 1991; 15 Sun, Junger, Yuan, Zhang, Bao, Qin (bib12) 2013 Jun; 31 Cacchio, Giordano, Colafarina, Rompe, Tavernese, Ioppolo (bib23) 2009 Nov; 91 Wang, Liu, Fu (bib24) 2007 Feb; 127 Bara, Synder (bib25) 2007 May; 9 Yu, Junger, Yuan, Jin, Zhao, Zheng (bib10) 2010 Mar; 298 Rompe, Rosendahl, Schollner, Theis (bib18) 2001 Jun; 387 Wang, Yang, Ko, Huang, Huang, Wang (bib27) 2009 Jun; 20 Weihs, Fuchs, Teuschl, Hartinger, Slezak, Mittermayr (bib11) 2014 Sep 26; 289 Ingber (bib9) 2006 May; 20 Furia, Juliano, Wade, Schaden, Mittermayr (bib21) 2010 Apr; 92 Wang, Wang, Yang, Weng, Hsu, Huang (bib4) 2003 Nov; 21 Wang, Wang, Chen, Chang, Huang, Sun (bib13) 2004 Mar 12; 279 Haupt (bib1) 1990 Elster, Stojadinovic, Forsberg, Shawen, Andersen, Schaden (bib28) 2010 Mar; 24 Huang, Holfeld, Schaden, Orgill, Ogawa (bib6) 2013 Sep; 19 Ha, Kim, Chung, An, Kwon (bib8) 2013 Oct 9; 168 Xu, Chen, Li, Huang, Xu, Yang (bib7) 2012 Jul 27; 287 Ayeni, Busse, Bhandari (bib29) 2011 Jan; 21 Wang, Chen, Chen, Yang (bib19) 2001 Jun; 387 Xu, Jiang, Chen, Xiong, Shi, Yuan (bib26) 2009 Jun; 33 Wang, Yang, Wang, Huang, Chio, Hsu (bib14) 2004 Jun; 19 Chen, Kuo, Yang, Wang, Sheen Chen, Huang (bib15) 2004 Mar; 34 Ikeda, Tomita, Takayama (bib17) 1999 Nov; 47 Notarnicola, Moretti, Tafuri, Gigliotti, Russo, Musci (bib22) 2010 Aug; 36 Wang, Wang, Yang (bib5) 2008 Aug; 128 Beutler, Regel, Pape, Machtens, Weinberg, Kremeike (bib16) 1999 Nov; 102 Zelle, Gollwitzer, Zlowodzki, Buhren (bib31) 2010 Mar; 24 Tischer, Milz, Weiler, Pautke, Hausdorf, Schmitz (bib3) 2008; 41 Stojadinovic, Kyle, Eberhardt, Shawen, Andersen, Forsberg (bib30) 2011 Jan 19; 93 Schaden, Fischer, Sailler (bib20) 2001 Jun; 387 Zelle (10.1016/j.ijsu.2015.10.003_bib31) 2010; 24 Ikeda (10.1016/j.ijsu.2015.10.003_bib17) 1999; 47 Elster (10.1016/j.ijsu.2015.10.003_bib28) 2010; 24 Stojadinovic (10.1016/j.ijsu.2015.10.003_bib30) 2011; 93 Wang (10.1016/j.ijsu.2015.10.003_bib24) 2007; 127 Ayeni (10.1016/j.ijsu.2015.10.003_bib29) 2011; 21 Sun (10.1016/j.ijsu.2015.10.003_bib12) 2013; 31 Furia (10.1016/j.ijsu.2015.10.003_bib21) 2010; 92 Beutler (10.1016/j.ijsu.2015.10.003_bib16) 1999; 102 Rompe (10.1016/j.ijsu.2015.10.003_bib18) 2001; 387 Cacchio (10.1016/j.ijsu.2015.10.003_bib23) 2009; 91 Wang (10.1016/j.ijsu.2015.10.003_bib27) 2009; 20 Haupt (10.1016/j.ijsu.2015.10.003_bib1) 1990 Xu (10.1016/j.ijsu.2015.10.003_bib7) 2012; 287 Wang (10.1016/j.ijsu.2015.10.003_bib13) 2004; 279 Wang (10.1016/j.ijsu.2015.10.003_bib19) 2001; 387 Wang (10.1016/j.ijsu.2015.10.003_bib5) 2008; 128 Chen (10.1016/j.ijsu.2015.10.003_bib15) 2004; 34 Ingber (10.1016/j.ijsu.2015.10.003_bib9) 2006; 20 Xu (10.1016/j.ijsu.2015.10.003_bib26) 2009; 33 Huang (10.1016/j.ijsu.2015.10.003_bib6) 2013; 19 Bara (10.1016/j.ijsu.2015.10.003_bib25) 2007; 9 Wang (10.1016/j.ijsu.2015.10.003_bib14) 2004; 19 Notarnicola (10.1016/j.ijsu.2015.10.003_bib22) 2010; 36 Valchanou (10.1016/j.ijsu.2015.10.003_bib2) 1991; 15 Ha (10.1016/j.ijsu.2015.10.003_bib8) 2013; 168 Tischer (10.1016/j.ijsu.2015.10.003_bib3) 2008; 41 Wang (10.1016/j.ijsu.2015.10.003_bib4) 2003; 21 Yu (10.1016/j.ijsu.2015.10.003_bib10) 2010; 298 Weihs (10.1016/j.ijsu.2015.10.003_bib11) 2014; 289 Schaden (10.1016/j.ijsu.2015.10.003_bib20) 2001; 387 |
| References_xml | – volume: 19 start-page: 555 year: 2013 Sep end-page: 564 ident: bib6 article-title: Mechanotherapy: revisiting physical therapy and recruiting mechanobiology for a new era in medicine publication-title: Trends Mol. Med. – volume: 127 start-page: 137 year: 2007 Feb end-page: 142 ident: bib24 article-title: The effects of extracorporeal shockwave on acute high-energy long bone fractures of the lower extremity publication-title: Arch. Orthop. Trauma Surg. – volume: 298 start-page: C457 year: 2010 Mar end-page: C464 ident: bib10 article-title: Shockwaves increase T-cell proliferation and IL-2 expression through ATP release, P2X7 receptors, and FAK activation publication-title: Am. J. Physiol. Cell Physiol. – volume: 387 start-page: 95 year: 2001 Jun end-page: 101 ident: bib19 article-title: Treatment of nonunions of long bone fractures with shock waves publication-title: Clin. Orthop. Relat. Res. – volume: 9 start-page: 254 year: 2007 May end-page: 258 ident: bib25 article-title: Nine-years experience with the use of shock waves for treatment of bone union disturbances publication-title: Ortop. Traumatol. Rehabil. – volume: 387 start-page: 102 year: 2001 Jun end-page: 111 ident: bib18 article-title: High-energy extracorporeal shock wave treatment of nonunions publication-title: Clin. Orthop. Relat. Res. – volume: 24 start-page: S66 year: 2010 Mar end-page: S70 ident: bib31 article-title: Extracorporeal shock wave therapy: current evidence publication-title: J. Orthop. Trauma – volume: 36 start-page: 1306 year: 2010 Aug end-page: 1313 ident: bib22 article-title: Extracorporeal shockwaves versus surgery in the treatment of pseudoarthrosis of the carpal scaphoid publication-title: Ultrasound Med. Biol. – volume: 33 start-page: 789 year: 2009 Jun end-page: 793 ident: bib26 article-title: Extracorporeal shock wave treatment in nonunions of long bone fractures publication-title: Int. Orthop. – volume: 24 start-page: 133 year: 2010 Mar end-page: 141 ident: bib28 article-title: Extracorporeal shock wave therapy for nonunion of the tibia publication-title: J. Orthop. Trauma – volume: 21 start-page: 74 year: 2011 Jan end-page: 75 ident: bib29 article-title: Using extracorporeal shock-wave therapy for healing long-bone nonunions publication-title: Clin. J. Sport Med. – year: 1990 ident: bib1 article-title: Enhancement of Fracture Healing with Extracorporeal Shock Waves – volume: 93 start-page: 187 year: 2011 Jan 19 end-page: 194 ident: bib30 article-title: Development of a prognostic naive bayesian classifier for successful treatment of nonunions publication-title: J. Bone Jt. Surg. Am. – volume: 34 start-page: 466 year: 2004 Mar end-page: 477 ident: bib15 article-title: Activation of extracellular signal-regulated kinase (ERK) and p38 kinase in shock wave-promoted bone formation of segmental defect in rats publication-title: Bone – volume: 15 start-page: 181 year: 1991 end-page: 184 ident: bib2 article-title: High energy shock waves in the treatment of delayed and nonunion of fractures publication-title: Int. Orthop. – volume: 41 start-page: 44 year: 2008 end-page: 53 ident: bib3 article-title: Dose-dependent new bone formation by extracorporeal shock wave application on the intact femur of rabbits publication-title: Eur. Surg. Res. – volume: 31 start-page: 1170 year: 2013 Jun end-page: 1180 ident: bib12 article-title: Shockwaves induce osteogenic differentiation of human mesenchymal stem cells through ATP release and activation of P2X7 receptors publication-title: Stem Cells – volume: 387 start-page: 90 year: 2001 Jun end-page: 94 ident: bib20 article-title: Extracorporeal shock wave therapy of nonunion or delayed osseous union publication-title: Clin. Orthop. Relat. Res. – volume: 92 start-page: 846 year: 2010 Apr end-page: 854 ident: bib21 article-title: Shock wave therapy compared with intramedullary screw fixation for nonunion of proximal fifth metatarsal metaphyseal-diaphyseal fractures publication-title: J. Bone Jt. Surg. Am. – volume: 20 start-page: 811 year: 2006 May end-page: 827 ident: bib9 article-title: Cellular mechanotransduction: putting all the pieces together again publication-title: FASEB J. – volume: 102 start-page: 839 year: 1999 Nov end-page: 847 ident: bib16 article-title: Extracorporeal shock wave therapy for delayed union of long bone fractures - preliminary results of a prospective cohort study publication-title: Unfallchirurg – volume: 128 start-page: 879 year: 2008 Aug end-page: 884 ident: bib5 article-title: Biological effects of extracorporeal shockwave in bone healing: a study in rabbits publication-title: Arch. Orthop. Trauma Surg. – volume: 21 start-page: 984 year: 2003 Nov end-page: 989 ident: bib4 article-title: Shock wave therapy induces neovascularization at the tendon-bone junction. A study in rabbits publication-title: J. Orthop. Res. – volume: 289 start-page: 27090 year: 2014 Sep 26 end-page: 27104 ident: bib11 article-title: Shock wave treatment enhances cell proliferation and improves wound healing by ATP release-coupled extracellular signal-regulated kinase (ERK) activation publication-title: J. Biol. Chem. – volume: 91 start-page: 2589 year: 2009 Nov end-page: 2597 ident: bib23 article-title: Extracorporeal shock-wave therapy compared with surgery for hypertrophic long-bone nonunions publication-title: J. Bone Jt. Surg. Am. – volume: 20 start-page: 298 year: 2009 Jun end-page: 303 ident: bib27 article-title: The effects of shockwave on bone healing and systemic concentrations of nitric oxide (NO), TGF-beta1, VEGF and BMP-2 in long bone non-unions publication-title: Nitric Oxide – volume: 287 start-page: 26200 year: 2012 Jul 27 end-page: 26212 ident: bib7 article-title: Optimal intensity shock wave promotes the adhesion and migration of rat osteoblasts via integrin beta1-mediated expression of phosphorylated focal adhesion kinase publication-title: J. Biol. Chem. – volume: 168 start-page: 4168 year: 2013 Oct 9 end-page: 4177 ident: bib8 article-title: Extracorporeal shock wave stimulates expression of the angiogenic genes via mechanosensory complex in endothelial cells: mimetic effect of fluid shear stress in endothelial cells publication-title: Int. J. Cardiol. – volume: 279 start-page: 10331 year: 2004 Mar 12 end-page: 10337 ident: bib13 article-title: Ras induction of superoxide activates ERK-dependent angiogenic transcription factor HIF-1alpha and VEGF-A expression in shock wave-stimulated osteoblasts publication-title: J. Biol. Chem. – volume: 19 start-page: 973 year: 2004 Jun end-page: 982 ident: bib14 article-title: Shockwave stimulates oxygen radical-mediated osteogenesis of the mesenchymal cells from human umbilical cord blood publication-title: J. Bone Min. Res. – volume: 47 start-page: 946 year: 1999 Nov end-page: 950 ident: bib17 article-title: Application of extracorporeal shock wave on bone: preliminary report publication-title: J. Trauma – volume: 93 start-page: 187 issue: 2 year: 2011 ident: 10.1016/j.ijsu.2015.10.003_bib30 article-title: Development of a prognostic naive bayesian classifier for successful treatment of nonunions publication-title: J. Bone Jt. Surg. Am. doi: 10.2106/JBJS.I.01649 – volume: 128 start-page: 879 issue: 8 year: 2008 ident: 10.1016/j.ijsu.2015.10.003_bib5 article-title: Biological effects of extracorporeal shockwave in bone healing: a study in rabbits publication-title: Arch. Orthop. Trauma Surg. doi: 10.1007/s00402-008-0663-1 – volume: 387 start-page: 95 year: 2001 ident: 10.1016/j.ijsu.2015.10.003_bib19 article-title: Treatment of nonunions of long bone fractures with shock waves publication-title: Clin. Orthop. Relat. Res. doi: 10.1097/00003086-200106000-00013 – volume: 33 start-page: 789 issue: 3 year: 2009 ident: 10.1016/j.ijsu.2015.10.003_bib26 article-title: Extracorporeal shock wave treatment in nonunions of long bone fractures publication-title: Int. Orthop. doi: 10.1007/s00264-008-0553-8 – volume: 387 start-page: 102 year: 2001 ident: 10.1016/j.ijsu.2015.10.003_bib18 article-title: High-energy extracorporeal shock wave treatment of nonunions publication-title: Clin. Orthop. Relat. Res. doi: 10.1097/00003086-200106000-00014 – volume: 19 start-page: 973 issue: 6 year: 2004 ident: 10.1016/j.ijsu.2015.10.003_bib14 article-title: Shockwave stimulates oxygen radical-mediated osteogenesis of the mesenchymal cells from human umbilical cord blood publication-title: J. Bone Min. Res. doi: 10.1359/JBMR.040121 – volume: 20 start-page: 298 issue: 4 year: 2009 ident: 10.1016/j.ijsu.2015.10.003_bib27 article-title: The effects of shockwave on bone healing and systemic concentrations of nitric oxide (NO), TGF-beta1, VEGF and BMP-2 in long bone non-unions publication-title: Nitric Oxide doi: 10.1016/j.niox.2009.02.006 – volume: 21 start-page: 984 issue: 6 year: 2003 ident: 10.1016/j.ijsu.2015.10.003_bib4 article-title: Shock wave therapy induces neovascularization at the tendon-bone junction. A study in rabbits publication-title: J. Orthop. Res. doi: 10.1016/S0736-0266(03)00104-9 – year: 1990 ident: 10.1016/j.ijsu.2015.10.003_bib1 – volume: 41 start-page: 44 issue: 1 year: 2008 ident: 10.1016/j.ijsu.2015.10.003_bib3 article-title: Dose-dependent new bone formation by extracorporeal shock wave application on the intact femur of rabbits publication-title: Eur. Surg. Res. doi: 10.1159/000128279 – volume: 36 start-page: 1306 issue: 8 year: 2010 ident: 10.1016/j.ijsu.2015.10.003_bib22 article-title: Extracorporeal shockwaves versus surgery in the treatment of pseudoarthrosis of the carpal scaphoid publication-title: Ultrasound Med. Biol. doi: 10.1016/j.ultrasmedbio.2010.05.004 – volume: 15 start-page: 181 issue: 3 year: 1991 ident: 10.1016/j.ijsu.2015.10.003_bib2 article-title: High energy shock waves in the treatment of delayed and nonunion of fractures publication-title: Int. Orthop. doi: 10.1007/BF00192289 – volume: 9 start-page: 254 issue: 3 year: 2007 ident: 10.1016/j.ijsu.2015.10.003_bib25 article-title: Nine-years experience with the use of shock waves for treatment of bone union disturbances publication-title: Ortop. Traumatol. Rehabil. – volume: 34 start-page: 466 issue: 3 year: 2004 ident: 10.1016/j.ijsu.2015.10.003_bib15 article-title: Activation of extracellular signal-regulated kinase (ERK) and p38 kinase in shock wave-promoted bone formation of segmental defect in rats publication-title: Bone doi: 10.1016/j.bone.2003.11.013 – volume: 298 start-page: C457 issue: 3 year: 2010 ident: 10.1016/j.ijsu.2015.10.003_bib10 article-title: Shockwaves increase T-cell proliferation and IL-2 expression through ATP release, P2X7 receptors, and FAK activation publication-title: Am. J. Physiol. Cell Physiol. doi: 10.1152/ajpcell.00342.2009 – volume: 127 start-page: 137 issue: 2 year: 2007 ident: 10.1016/j.ijsu.2015.10.003_bib24 article-title: The effects of extracorporeal shockwave on acute high-energy long bone fractures of the lower extremity publication-title: Arch. Orthop. Trauma Surg. doi: 10.1007/s00402-006-0236-0 – volume: 20 start-page: 811 issue: 7 year: 2006 ident: 10.1016/j.ijsu.2015.10.003_bib9 article-title: Cellular mechanotransduction: putting all the pieces together again publication-title: FASEB J. doi: 10.1096/fj.05-5424rev – volume: 102 start-page: 839 issue: 11 year: 1999 ident: 10.1016/j.ijsu.2015.10.003_bib16 article-title: Extracorporeal shock wave therapy for delayed union of long bone fractures - preliminary results of a prospective cohort study publication-title: Unfallchirurg doi: 10.1007/s001130050492 – volume: 24 start-page: 133 issue: 3 year: 2010 ident: 10.1016/j.ijsu.2015.10.003_bib28 article-title: Extracorporeal shock wave therapy for nonunion of the tibia publication-title: J. Orthop. Trauma doi: 10.1097/BOT.0b013e3181b26470 – volume: 19 start-page: 555 issue: 9 year: 2013 ident: 10.1016/j.ijsu.2015.10.003_bib6 article-title: Mechanotherapy: revisiting physical therapy and recruiting mechanobiology for a new era in medicine publication-title: Trends Mol. Med. doi: 10.1016/j.molmed.2013.05.005 – volume: 24 start-page: S66 issue: Suppl. 1 year: 2010 ident: 10.1016/j.ijsu.2015.10.003_bib31 article-title: Extracorporeal shock wave therapy: current evidence publication-title: J. Orthop. Trauma doi: 10.1097/BOT.0b013e3181cad510 – volume: 287 start-page: 26200 issue: 31 year: 2012 ident: 10.1016/j.ijsu.2015.10.003_bib7 article-title: Optimal intensity shock wave promotes the adhesion and migration of rat osteoblasts via integrin beta1-mediated expression of phosphorylated focal adhesion kinase publication-title: J. Biol. Chem. doi: 10.1074/jbc.M112.349811 – volume: 168 start-page: 4168 issue: 4 year: 2013 ident: 10.1016/j.ijsu.2015.10.003_bib8 article-title: Extracorporeal shock wave stimulates expression of the angiogenic genes via mechanosensory complex in endothelial cells: mimetic effect of fluid shear stress in endothelial cells publication-title: Int. J. Cardiol. doi: 10.1016/j.ijcard.2013.07.112 – volume: 279 start-page: 10331 issue: 11 year: 2004 ident: 10.1016/j.ijsu.2015.10.003_bib13 article-title: Ras induction of superoxide activates ERK-dependent angiogenic transcription factor HIF-1alpha and VEGF-A expression in shock wave-stimulated osteoblasts publication-title: J. Biol. Chem. doi: 10.1074/jbc.M308013200 – volume: 31 start-page: 1170 issue: 6 year: 2013 ident: 10.1016/j.ijsu.2015.10.003_bib12 article-title: Shockwaves induce osteogenic differentiation of human mesenchymal stem cells through ATP release and activation of P2X7 receptors publication-title: Stem Cells doi: 10.1002/stem.1356 – volume: 387 start-page: 90 year: 2001 ident: 10.1016/j.ijsu.2015.10.003_bib20 article-title: Extracorporeal shock wave therapy of nonunion or delayed osseous union publication-title: Clin. Orthop. Relat. Res. doi: 10.1097/00003086-200106000-00012 – volume: 92 start-page: 846 issue: 4 year: 2010 ident: 10.1016/j.ijsu.2015.10.003_bib21 article-title: Shock wave therapy compared with intramedullary screw fixation for nonunion of proximal fifth metatarsal metaphyseal-diaphyseal fractures publication-title: J. Bone Jt. Surg. Am. doi: 10.2106/JBJS.I.00653 – volume: 91 start-page: 2589 issue: 11 year: 2009 ident: 10.1016/j.ijsu.2015.10.003_bib23 article-title: Extracorporeal shock-wave therapy compared with surgery for hypertrophic long-bone nonunions publication-title: J. Bone Jt. Surg. Am. doi: 10.2106/JBJS.H.00841 – volume: 47 start-page: 946 issue: 5 year: 1999 ident: 10.1016/j.ijsu.2015.10.003_bib17 article-title: Application of extracorporeal shock wave on bone: preliminary report publication-title: J. Trauma doi: 10.1097/00005373-199911000-00024 – volume: 289 start-page: 27090 issue: 39 year: 2014 ident: 10.1016/j.ijsu.2015.10.003_bib11 article-title: Shock wave treatment enhances cell proliferation and improves wound healing by ATP release-coupled extracellular signal-regulated kinase (ERK) activation publication-title: J. Biol. Chem. doi: 10.1074/jbc.M114.580936 – volume: 21 start-page: 74 issue: 1 year: 2011 ident: 10.1016/j.ijsu.2015.10.003_bib29 article-title: Using extracorporeal shock-wave therapy for healing long-bone nonunions publication-title: Clin. J. Sport Med. doi: 10.1097/01.jsm.0000393479.96218.d7 |
| SSID | ssj0040818 |
| Score | 2.2764611 |
| SecondaryResourceType | review_article |
| Snippet | Fracture non-unions are still a challenging problem in orthopedics. The treatment of non-unions remains highly individualized, complex, and demanding. In most... Abstract Fracture non-unions are still a challenging problem in orthopedics. The treatment of non-unions remains highly individualized, complex, and demanding.... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 179 |
| SubjectTerms | ESWT Extracorporeal shockwave therapy Fracture Healing Fractures, Ununited - therapy High-Energy Shock Waves - therapeutic use Humans Non-healing fractures Non-union Pseudarthroses Surgery |
| Title | Extracorporeal shockwave therapy (ESWT) – First choice treatment of fracture non-unions? |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S1743919115012674 https://www.clinicalkey.es/playcontent/1-s2.0-S1743919115012674 https://dx.doi.org/10.1016/j.ijsu.2015.10.003 https://www.ncbi.nlm.nih.gov/pubmed/26454164 https://www.proquest.com/docview/1753444115 |
| Volume | 24 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LS8NAEB58XLyI4qs-ygoeFIlNsnmeRKWlKnixxeJlyW52MUXS0qY-LuJ_8B_6S5zNoyC-wNwSdplkMvPtN-zMLMCe0G3gkNcaXuBzwwmENCLp2YYSwlNIGJTN8yzfK6_ddS56bm8GzqpaGJ1WWWJ_gek5WpdPGqU2G8MkaVznXBrDDaQ0lu35uicodYK8iK93WqGxo1u2FUWRepc5tMrCmSLHK-ljJIpLoHuUZ3jRnxann8hnvgi1lmCxZI_kpHjBZZiR6QrcNp-yEQKbbkmMtI-M7xDjHqMHSYriqmey37y-6RyQ99c30kqQ7hHEPAQIMs0yJwNFlK6XmowkSQepMUm1OR6vQrfV7Jy1jfLIBEO4YZAZbkypkmGgROBxaQmMFiJqBlEY-7YpKRVxKJTiphPZLo9dLvwI1yPpOhy1KDinazCHUuQGEGl7PPZjy-SmcOLQx-FItqSDl-QYpdXAqnTFRNlPXB9rcc-qxLE-0_plWr_6Geq3BofTOcOim8avo2n1C1hVJ4rIxhDsf53lfzdLjkvnHDOLjW1msi8GVAN3OvOTDf4pcbeyD4bOqXdcolQOJigJg0HUF0qowXphONPvtnUvNXSTzX9K3YIFfVek1mzDXDaayB0kSBmvw-zRi1WH-ZPzy_ZVPfeHDwUQESk |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3JTsMwEB1BOcAFgdjKaiQOIBSafTkhQK0KlF4oouJixY4tWqG0alOWG__AH_IljLNJiE0ix8TWJJOZ5zfyzBhgj6s2cMhrNdf3mGb7XGihcE1Ncu5KJAzSZGmWb9tt3tgXXac7BWdFLYxKq8yxP8P0FK3zO7Vcm7Vhr1e7Trk0hhtIaQzT9expmEE24KnzG867pwUc26pnW1YVqbaZAyOvnMmSvHp9DEVxDXSO0hQv66fV6Sf2ma5CjQWYz-kjOcnecBGmRLwEd_XnZITIpnoSI-8j43sEuafwUZCsuuqF7NevbzsH5P31jTR6yPcIgh4iBCnTzMlAEqkKpiYjQeJBrE1iZY_Hy3DTqHfOmlp-ZoLGncBPNCeyLCkCX3LfZcLgGC6Elu6HQeSZurAsHgVcSqbboemwyGHcC3FBEo7NUI2cMWsFKihFrAERpssiLzJ0pnM7CjwcjvoVNl6CYZhWBaPQFeV5Q3F1rsUDLTLH-lTplyr9qnuo3yoclnOGWTuNX0dbxS-gRaEoQhtFtP91lvfdLDHOvXNMDTo2qU6_WFAVnHLmJyP8U-JuYR8UvVNtuYSxGExQEkaDqC-UUIXVzHDK7zZVMzX0k_V_St2B2WbnqkVb5-3LDZhTT7I8m02oJKOJ2EK2lLDt1Bs-AL9CEbw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Extracorporeal+shockwave+therapy+%28ESWT%29+%E2%80%93+First+choice+treatment+of+fracture+non-unions%3F&rft.jtitle=International+journal+of+surgery+%28London%2C+England%29&rft.au=Schaden%2C+Wolfgang&rft.au=Mittermayr%2C+Rainer&rft.au=Haffner%2C+Nicolas&rft.au=Smolen%2C+Daniel&rft.date=2015-12-01&rft.issn=1743-9191&rft.volume=24&rft.spage=179&rft.epage=183&rft_id=info:doi/10.1016%2Fj.ijsu.2015.10.003&rft.externalDBID=ECK1-s2.0-S1743919115012674&rft.externalDocID=1_s2_0_S1743919115012674 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F17439191%2FS1743919115X00161%2Fcov150h.gif |