Metabolomic investigation of urinary extracellular vesicles for early detection and screening of lung cancer

• Published in: Journal of nanobiotechnology Vol. 21; no. 1; pp. 153 - 10
• Main Authors: Yang, Qinsi, Luo, Jiaxin, Xu, Hao, Huang, Liu, Zhu, Xinxi, Li, Hengrui, Yang, Rui, Peng, Bo, Sun, Da, Zhu, Qingfu, Liu, Fei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.05.2023; BioMed Central; BMC
• Subjects: Analysis; Antibodies; Benzenoids; Biomarkers; Biomarkers, Tumor - metabolism; Carcinogenesis; Carcinogens; Care and treatment; Carnitine; Cell proliferation; Chromatography; Diagnosis; Early Detection of Cancer; Early diagnosis; Extracellular vesicles; Extracellular Vesicles - metabolism; Gene expression; Genetic aspects; Health aspects; Humans; Immune response; Invasiveness; Lipids; Lung cancer; Lung cancer, Non-small cell; Lung Neoplasms - diagnosis; Lung Neoplasms - metabolism; Machine learning; Marker panels; Metabolism; Metabolites; Metabolomics; Metastases; Organic acids; Proteins; Reproducibility of Results; Tumors; Urine; Vesicles; China; United Kingdom > UK; United States > US; Extracellular vesicles; Metabolomics; Early diagnosis; Lung cancer

Lung cancer is a prevalent cancer type worldwide that often remains asymptomatic in its early stages and is frequently diagnosed at an advanced stage with a poor prognosis due to the lack of effective diagnostic techniques and molecular biomarkers. However, emerging evidence suggests that extracellu...