The Role of Reactive Oxygen Species in β-Adrenergic Signaling in Cardiomyocytes from Mice with the Metabolic Syndrome - Llano-Diez, Monica; Sinclair, Jon; Yamada, Takashi; Zong, Mei; Fauconnier, Jeremy; Zhang, Shi-Jin; Katz, Abram; Jardemark, Kent; Westerblad, Håkan; Andersson, Daniel C.; Lanner, Johanna T. (PloS one, 2016)
Keywords: Adrenergic beta-Agonists - pharmacology; Adrenergic transmission; Animal models; Animals; Antioxidants; Biochemistry; Biochemistry, Molecular Biology; Biology and Life Sciences; Calcium (intracellular); Calcium (mitochondrial); Calcium - metabolism; Calcium signalling; Cardiology and cardiovascular system; Cardiomyocytes; Cardiomyopathies - etiology; Cardiomyopathies - metabolism; Cardiomyopathies - pathology; Cardiovascular diseases; Cellular manufacture; Confocal microscopy; Diabetes; Diet; Diet, High-Fat - adverse effects; Electric Stimulation; Experiments; Fluorescence; Fluorescent dyes; Fluorescent indicators; Gene expression; Health sciences; Heart; Heart diseases; Heart failure; High fat diet; Human health and pathology; Hydrogen Peroxide - pharmacology; Hyperactivity; Immunofluorescence; Insulin resistance; Isoproterenol - pharmacology; Kinases; Life Sciences; Male; Medicine and Health Sciences; Metabolic disorders; Metabolic syndrome; Metabolic Syndrome - etiology; Metabolic Syndrome - metabolism; Metabolic Syndrome - pathology; Mice; Mice, Inbred C57BL; Microscopy; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Muscle contraction; Musculoskeletal system; Myocardial Contraction - drug effects; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Nervous system; Obesity - etiology; Obesity - metabolism; Obesity - pathology; Organ Culture Techniques; Oxidative stress; Oxygen; Pharmacology; Physiology; Primary Cell Culture; Reactive oxygen species; Reactive Oxygen Species - metabolism; Receptors, Adrenergic, beta - metabolism; Research and Analysis Methods; Rodents; Signal Transduction; Stimulation; Sympathetic nervous system; Denmark; Sweden