Exploring genetic diversity and variation of Ovar-DRB1 gene in Sudan Desert Sheep using targeted next-generation sequencing

• Published in: BMC genomics Vol. 25; no. 1; pp. 160 - 15
• Main Authors: Salim, Bashir, Nakao, Ryo, Chatanga, Elisha, Marcuzzi, Olivia, Eissawi, Muna Ahmed, Almathen, Faisal, Hanotte, Olivier, Giovambattista, Guillermo
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.02.2024; BioMed Central; BMC
• Subjects: Adaptive immunity; Alleles; Allelomorphism; Amino acids; Analysis; Antigens; Biological diversity; Breeding; Clustering; Deserts; Differentiation; Disease resistance; DNA sequencing; Drb1 protein; Genes; Genetic analysis; Genetic aspects; Genetic diversity; Genetic factors; Genetic testing; Genetic variation; Health aspects; Immune response; Livestock; Lymphocytes T; Major histocompatibility complex; Maximum likelihood method; Medical research; Medicine, Experimental; Next-generation sequencing; Nucleotide sequencing; Ovar-DRB1 gene; Population genetics; Population studies; Populations; Sheep; Sheep breeds; Software; Sudan Desert Sheep; T cells; Sudan; United States > US; Sudan Desert Sheep; Genetic diversity; Next-generation sequencing; Ovar-DRB1 gene

The Ovar-DRB1 gene, a crucial element of the Major Histocompatibility Complex (MHC) Class II region, initiates adaptive immunity by presenting antigens to T-cells. Genetic diversity in sheep, particularly in MHC Class II genes like Ovar-DRB1, directly influences the specturm of presented antigens im...