In vitro inflammation and toxicity assessment of pre- and post-incinerated organomodified nanoclays to macrophages using high-throughput screening approaches - Stueckle, Todd A.; Jensen, Jake; Coyle, Jayme P.; Derk, Raymond; Wagner, Alixandra; Dinu, Cerasela Zoica; Kornberg, Tiffany G.; Friend, Sherri A.; Dozier, Alan; Agarwal, Sushant; Gupta, Rakesh K.; Rojanasakul, Liying W. (Particle and fibre toxicology, 2024)
Keywords: Ablation; Air pollution; Airborne particulates; Ammonium; Animals; Apoptosis; Cathepsin B; Cathepsin B - metabolism; Cathepsin B - pharmacology; Cathepsins; Cell membranes; Cell viability; Clay; Coatings; Combustion; Comparative analysis; Composite materials; Cytokines; Cytokines - metabolism; Cytotoxicity; Damage patterns; Depolarization; Development and progression; Environmental aspects; Exposure; Fibrosis; Fourier transforms; Health aspects; Health risks; High-throughput screening; High-Throughput Screening Assays; Humans; IL-1β; Immune system; In vitro models; Incineration; Inflammasomes; Inflammation; Inflammation - chemically induced; Inflammation - metabolism; Interleukin-1beta - metabolism; Lavage; Life cycles; Lipopolysaccharides; Lipopolysaccharides - pharmacology; Lung diseases; Lungs; Macrophages; Male; Mice; Montmorillonite; Morphology; Nanoclay; Nanocomposites; Nanoparticles; NF-κB protein; Occupational exposure; Organic coating; Organic coatings; Priming; Pyroptosis; Risk factors; Silica; Silicates; Surface chemistry; Toxicity; United Kingdom; United States; In vitro models; Incineration; Mouse; Human lung cells; High-throughput screening; Silicates; Nanoclay; Organic coating