Management of acquired resistance to EGFR TKI–targeted therapy in advanced non-small cell lung cancer

• Published in: Molecular cancer Vol. 17; no. 1; pp. 38 - 14
• Main Authors: Wu, Shang-Gin, Shih, Jin-Yuan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.02.2018; BioMed Central; BMC
• Subjects: Animals; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - metabolism; Care and treatment; Complications and side effects; Development and progression; Diagnosis; Dosage and administration; Drug Resistance, Neoplasm - genetics; ErbB Receptors - genetics; ErbB Receptors - metabolism; Gefitinib; Humans; Lung cancer, Non-small cell; Lung Neoplasms - drug therapy; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Protein Kinase Inhibitors - therapeutic use; Review; United States

Recent advances in diagnosis and treatment are enabling a more targeted approach to treating lung cancers. Therapy targeting the specific oncogenic driver mutation could inhibit tumor progression and provide a favorable prognosis in clinical practice. Activating mutations of epidermal growth factor...