New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells

• Published in: Experimental & molecular medicine Vol. 52; no. 2; pp. 281 - 292
• Main Authors: Alburquerque-González, Begoña, Bernabé-García, Manuel, Montoro-García, Silvia, Bernabé-García, Ángel, Rodrigues, Priscila Campioni, Ruiz Sanz, Javier, López-Calderón, Fernando F., Luque, Irene, Nicolas, Francisco José, Cayuela, María Luisa, Salo, Tuula, Pérez-Sánchez, Horacio, Conesa-Zamora, Pablo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2020; Springer Nature B.V; Nature Publishing Group; 생화학분자생물학회
• Subjects: 101/28; 13; 13/109; 14; 14/19; 38; 38/61; 631/80/84/1756; 64/116; 692/308/153; 692/699/67/1504/1885/1393; 82/29; Actin; Adenocarcinoma; Antidepressants; Biomedical and Life Sciences; Biomedicine; Colorectal cancer; Colorectal carcinoma; Cytoskeleton; Danio rerio; Epidermal growth factor; Epidermal growth factor receptors; FDA approval; Imipramine; Invasiveness; Lamellipodia; Medical Biochemistry; Metastases; Metastasis; Molecular Medicine; Prognosis; Proteins; Pseudopodia; Scanning; Stem Cells; Tumors; 생화학

Serrated adenocarcinoma (SAC) is more invasive, has worse outcomes than conventional colorectal carcinoma (CRC), and is characterized by frequent resistance to anti-epidermal growth factor receptor (EGFR) and overexpression of fascin1, a key protein in actin bundling that plays a causative role in t...