Gut dysbiosis induces the development of depression-like behavior through abnormal synapse pruning in microglia-mediated by complement C3

• Published in: Microbiome Vol. 12; no. 1; pp. 34 - 25
• Main Authors: Hao, Wenzhi, Ma, Qingyu, Wang, Lu, Yuan, Naijun, Gan, Hua, He, Liangliang, Li, Xiaojuan, Huang, Junqing, Chen, Jiaxu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.02.2024; BioMed Central; BMC
• Subjects: Animal models; Animals; Antibiotics; Antidepressants; Brain research; Cognitive ability; Complement activation; Complement C3; Complement component C3; Complement system; Depression; Depression - microbiology; Dysbacteriosis; Dysbiosis; Emotional disorders; Fecal microbiota transplantation; Fecal microflora; Feces; Germfree; Gut microbiota; Herbal medicine; Imipenem; Intestinal microflora; Laboratory animals; Lipopolysaccharides; Medical research; Mental depression; Metabolites; Metronidazole; Mice; Microbiomes; Microbiota; Microbiota (Symbiotic organisms); Microenvironments; Microglia; Microglia - physiology; Oral administration; Pathogenesis; Phytochemicals; Postsynaptic density; Prefrontal cortex; Signal transduction; Specific pathogen free; Synapses; Synapses - physiology; Synapsin; Synaptic depression; Synaptic pruning; Transplantation; China; Gut microbiota; Synaptic pruning; Depression; Complement C3; Fecal microbiota transplantation; Microglia

Remodeling eubiosis of the gut microenvironment may contribute to preventing the occurrence and development of depression. Mounting experimental evidence has shown that complement C3 signaling is associated with the pathogenesis of depression, and disruption of the gut microbiota may be an underlyin...