Gut dysbiosis induces the development of depression-like behavior through abnormal synapse pruning in microglia-mediated by complement C3 - Hao, Wenzhi; Ma, Qingyu; Wang, Lu; Yuan, Naijun; Gan, Hua; He, Liangliang; Li, Xiaojuan; Huang, Junqing; Chen, Jiaxu (Microbiome, 2024)
Keywords: Animal models; Animals; Antibiotics; Antidepressants; Brain research; Cognitive ability; Complement activation; Complement C3; Complement component C3; Complement system; Depression; Depression - microbiology; Dysbacteriosis; Dysbiosis; Emotional disorders; Fecal microbiota transplantation; Fecal microflora; Feces; Germfree; Gut microbiota; Herbal medicine; Imipenem; Intestinal microflora; Laboratory animals; Lipopolysaccharides; Medical research; Mental depression; Metabolites; Metronidazole; Mice; Microbiomes; Microbiota; Microbiota (Symbiotic organisms); Microenvironments; Microglia; Microglia - physiology; Oral administration; Pathogenesis; Phytochemicals; Postsynaptic density; Prefrontal cortex; Signal transduction; Specific pathogen free; Synapses; Synapses - physiology; Synapsin; Synaptic depression; Synaptic pruning; Transplantation; China; Gut microbiota; Synaptic pruning; Depression; Complement C3; Fecal microbiota transplantation; Microglia