Disulfidptosis-related subtype and prognostic signature in prostate cancer

• Published in: Biology direct Vol. 19; no. 1; pp. 97 - 17
• Main Authors: Kang, Zhen, Wan, Zheng-Hua, Gao, Rui-Cheng, Chen, Dong-Ning, Zheng, Qing-Shui, Xue, Xue-Yi, Xu, Ning, Wei, Yong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 23.10.2024; BioMed Central; BMC
• Subjects: Amino Acid Transport System y+ - genetics; Amino Acid Transport System y+ - metabolism; Antibodies; Apoptosis; Cancer therapies; Care and treatment; Cell adhesion & migration; Cell death; Cell Line, Tumor; Cell migration; Cholecystokinin; Classification; Cluster analysis; Clustering; CRISPR; Cytoskeleton; Development and progression; Dextrose; Flow cytometry; Gene Expression Regulation, Neoplastic; Gene sequencing; Genes; Glucose; Glucose transporter; Health aspects; Humans; Immune checkpoint inhibitors; Immune system; Immunotherapy; Labels; Machine learning; Male; Medical prognosis; Medical research; Medicine, Experimental; Metastases; Mutation; Neomycin; Patients; Prognosis; Prostate cancer; Prostatic Neoplasms - genetics; Prostatic Neoplasms - metabolism; Protein binding; Proteins; Risk groups; Sensitivity analysis; Signatures; Tumor cells; Tumor Microenvironment; Tumors; Wound healing; China

Disulfidptosis refers to cell death caused by the accumulation and bonding of disulfide in the cytoskeleton protein of SLC7A11-high level cells under glucose deprivation. However, the role of disulfidptosis-related genes (DRGs) in prostate cancer (PCa) classification and regulation of the tumor micr...