iPSC-derived neural precursor cells: potential for cell transplantation therapy in spinal cord injury

• Published in: Cellular and molecular life sciences : CMLS Vol. 75; no. 6; pp. 989 - 1000
• Main Authors: Nagoshi, Narihito, Okano, Hideyuki
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.03.2018; Springer Nature B.V
• Subjects: Abnormalities; animal injuries; Animal models; Animals; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cell Differentiation; Cell Transformation, Neoplastic; cell transplantation; Effectiveness; Embryo cells; embryonic stem cells; Epigenetics; Ethics; Fetuses; Humans; induced pluripotent stem cells; Induced Pluripotent Stem Cells - cytology; Life Sciences; momentum; Neural networks; Neural Stem Cells - cytology; Neural Stem Cells - transplantation; Patients; Pluripotency; Precursors; Quality management; Recovery of Function; Regeneration; Review; Somatic cells; spinal cord; Spinal cord injuries; Spinal Cord Injuries - pathology; Spinal Cord Injuries - therapy; Stem cell transplantation; Stem cells; Transfection; Transplantation; Transplants & implants; Tumorigenicity; Regeneration; Mechanisms for functional recovery; Stem cell graft; Safety issue; Central nervous system

A number of studies have demonstrated that transplantation of neural precursor cells (NPCs) promotes functional recovery after spinal cord injury (SCI). However, the NPCs had been mostly harvested from embryonic stem cells or fetal tissue, raising the ethical concern. Yamanaka and his colleagues est...