Serum lncRNA ITGB2-AS1 and ICAM-1 as novel biomarkers for rheumatoid arthritis and osteoarthritis diagnosis

• Published in: BMC medical genomics Vol. 17; no. 1; pp. 247 - 12
• Main Authors: Selim, Aliaa M., Elsabagh, Yumn A., El-Sawalhi, Maha M., Ismail, Nabila A., Senousy, Mahmoud A.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.10.2024; BioMed Central; BMC
• Subjects: Adult; Aged; Analysis; Antigens; Antisense RNA; Arthritis, Rheumatoid - blood; Arthritis, Rheumatoid - diagnosis; Arthritis, Rheumatoid - genetics; Biological markers; Biomarkers; Biomarkers - blood; Bone cancer; Case-Control Studies; Cell adhesion; Development and progression; Diagnosis; Disease; Epigenetics; Female; Gene expression; Genetic aspects; Glycoproteins; Health aspects; Humans; ICAM-1; Inflammation; Integrin; Integrins; Intercellular adhesion molecule 1; Intercellular Adhesion Molecule-1 - blood; Intercellular Adhesion Molecule-1 - genetics; ITGB2-AS1; Kidney cancer; Knee; Leukocytes; Ligands; Male; Measurement; Middle Aged; Multivariate analysis; Non-coding RNA; Osteoarthritis; Osteoarthritis - blood; Osteoarthritis - diagnosis; Osteoarthritis - genetics; Osteoarthritis, Knee - blood; Osteoarthritis, Knee - diagnosis; Osteoarthritis, Knee - genetics; Proteins; Rheumatoid arthritis; Rheumatoid factor; Rheumatology; RNA; RNA, Long Noncoding - blood; RNA, Long Noncoding - genetics; Egypt; United States > US; Germany; ITGB2-AS1; ICAM-1; Integrin; Osteoarthritis; Rheumatoid arthritis

The complete circulating long non-coding RNAs (lncRNAs) signature of rheumatoid arthritis (RA) and osteoarthritis (OA) is still uncovered. The lncRNA integrin subunit beta 2 (ITGB2)-anti-sense RNA 1 (ITGB2-AS1) affects ITGB2 expression; however, there is a gap in knowledge regarding its expression a...