Fungal endophytes of Taxus species and regulatory effect of two strains on taxol synthesis

• Published in: BMC microbiology Vol. 24; no. 1; pp. 291 - 13
• Main Authors: Zhang, Hongshan, Lin, Wanting, Ma, Ruoyun, Zang, Yue, Hou, Kailin, Xu, Zhen, Xi, Xiaoyun, Zhang, Weiting, Tang, Shini, Liang, Xueshuang, Sun, Yiming, Shen, Chenjia
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.08.2024; BioMed Central; BMC
• Subjects: Alternaria; Alternaria - classification; Alternaria - genetics; Alternaria - isolation & purification; Alternaria - metabolism; Analysis; Antineoplastic drugs; Bar codes; Biological diversity; Biosynthesis; Control; Correlation analysis; Diversity; DNA, Fungal - genetics; DNA, Ribosomal Spacer - genetics; Drug development; Endangered species; Endophytes; Endophytes - classification; Endophytes - genetics; Endophytes - isolation & purification; Endophytes - metabolism; Endophytic fungi; Fungi; Fungi - classification; Fungi - genetics; Fungi - isolation & purification; Fungi - metabolism; Gene expression; Genera; Genetic aspects; Health aspects; Host plants; Identification and classification; Inoculation; ITS sequencing; Leaves; Metabolites; Metabolomics; Microorganisms; Natural resources; Paclitaxel; Paclitaxel - biosynthesis; Phylogenetics; Phylogeny; Plant growth; Plant growth promoting substances; Protection and preservation; Screening; Taxol; Taxus; Taxus - microbiology; Transcriptomics; Trees; China; United States > US; Endophytic fungi; ITS sequencing; Taxus; Correlation analysis; Diversity

Taxol, derived from Taxus trees, is a valuable natural resource for the development of anticancer drugs. Endophytic fungi from Taxus trees are a promising alternative source of Taxol. However, the impact of plant-endophytic microbial interaction on the host's Taxol biosynthesis is largely unkno...