Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury

• Published in: Nature medicine Vol. 12; no. 7; pp. 829 - 834
• Main Authors: Okano, Hideyuki, Okada, Seiji, Nakamura, Masaya, Katoh, Hiroyuki, Miyao, Tamaki, Shimazaki, Takuya, Ishii, Ken, Yamane, Junichi, Yoshimura, Akihiko, Iwamoto, Yukihide, Toyama, Yoshiaki
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01.07.2006
• Subjects: Animals; Astrocytes - physiology; Central nervous system; Cytokines; Disease Models, Animal; Green Fluorescent Proteins - genetics; Infiltration; Inflammation; Lesions; Medical research; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Nervous system; Signal Transduction; Spinal cord injuries; Spinal Cord Injuries - genetics; Spinal Cord Injuries - physiopathology; STAT3 Transcription Factor - deficiency; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - physiology; Studies; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins - deficiency; Suppressor of Cytokine Signaling Proteins - genetics; Suppressor of Cytokine Signaling Proteins - physiology; Transgenic animals; Wound Healing

In the injured central nervous system (CNS), reactive astrocytes form a glial scar and are considered to be detrimental for axonal regeneration, but their function remains elusive. Here we show that reactive astrocytes have a crucial role in wound healing and functional recovery by using mice with a...