Sustained gut dysbiosis and intestinal inflammation show correlation with weight gain in person with chronic HIV infection on antiretroviral therapy

• Published in: BMC microbiology Vol. 24; no. 1; pp. 274 - 13
• Main Authors: Ishizaka, Aya, Koga, Michiko, Mizutani, Taketoshi, Suzuki, Yutaka, Matano, Tetsuro, Yotsuyanagi, Hiroshi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.07.2024; BioMed Central; BMC
• Subjects: Adult; Age; Age related diseases; Anti-Retroviral Agents - therapeutic use; Antiretroviral agents; Antiretroviral drugs; Antiretroviral therapy; Antiviral agents; Bacteria; Bacteria - classification; Bacteria - isolation & purification; Biological diversity; Body Mass Index; Body size; Body weight; Care and treatment; Cell activation; Chemokines; Chronic infection; Chronic inflammation; Composition; Correlation; Correlation analysis; Cytokines; Development and progression; Digestive system; Drug therapy; Dysbacteriosis; Dysbiosis - microbiology; Fatty acids; Female; Gastrointestinal Microbiome - drug effects; Gastrointestinal tract; Glucose metabolism; Health aspects; Highly active antiretroviral therapy; HIV; HIV (Viruses); HIV infection; HIV Infections - complications; HIV Infections - drug therapy; HIV Infections - microbiology; HIV-1; Human immunodeficiency virus; Humans; Immunology; Infections; Inflammation; Interleukin 16; Interleukins; Intestinal microflora; Intestine; Intestines - microbiology; Longitudinal Studies; Macrophages; Male; Metabolic disorders; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Middle Aged; Monocyte chemoattractant protein; Monocyte chemoattractant protein 1; Monocytes; Parabacteroides; Pathogenesis; Physiological aspects; Prevention; Protein turnover; Risk factors; Sexual orientation; Translocation; Weight Gain - drug effects; Japan; HIV; Chronic inflammation; Microbiota

Person with human immunodeficiency virus type-1 (PWH) are prone to chronic inflammation due to residual viral production, even with antiretroviral therapy (ART), which increases the risk of age-related diseases. There is also limited information on changes in the intestinal environment of PWH during...