Regulation of circulating sclerostin levels by sex steroids in women and in men
Sex steroids are important regulators of bone turnover, but the mechanisms of their effects on bone remain unclear. Sclerostin is an inhibitor of Wnt signaling, and circulating estrogen (E) levels are inversely associated with sclerostin levels in postmenopausal women. To directly test for sex stero...
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Published in | Journal of bone and mineral research Vol. 26; no. 1; pp. 27 - 34 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.01.2011
Wiley Wiley Subscription Services, Inc |
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Abstract | Sex steroids are important regulators of bone turnover, but the mechanisms of their effects on bone remain unclear. Sclerostin is an inhibitor of Wnt signaling, and circulating estrogen (E) levels are inversely associated with sclerostin levels in postmenopausal women. To directly test for sex steroid regulation of sclerostin levels, we examined effects of E treatment of postmenopausal women or selective withdrawal of E versus testosterone (T) in elderly men on circulating sclerostin levels. E treatment of postmenopausal women (n = 17) for 4 weeks led to a 27% decrease in serum sclerostin levels [versus +1% in controls (n = 18), p < .001]. Similarly, in 59 elderly men, we eliminated endogenous E and T production and studied them under conditions of physiologic T and E replacement, and then following withdrawal of T or E, we found that E, but not T, prevented increases in sclerostin levels following induction of sex steroid deficiency. In both sexes, changes in sclerostin levels correlated with changes in bone‐resorption, but not bone‐formation, markers (r = 0.62, p < .001, and r = 0.33, p = .009, for correlations with changes in serum C‐terminal telopeptide of type 1 collagen in the women and men, respectively). Our studies thus establish that in humans, circulating sclerostin levels are reduced by E but not by T. Moreover, consistent with recent data indicating important effects of Wnts on osteoclastic cells, our findings suggest that in humans, changes in sclerostin production may contribute to effects of E on bone resorption. © 2011 American Society for Bone and Mineral Research. |
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AbstractList | Sex steroids are important regulators of bone turnover, but the mechanisms of their effects on bone remain unclear. Sclerostin is an inhibitor of Wnt signaling, and circulating estrogen (E) levels are inversely associated with sclerostin levels in postmenopausal women. To directly test for sex steroid regulation of sclerostin levels, we examined effects of E treatment of postmenopausal women or selective withdrawal of E versus testosterone (T) in elderly men on circulating sclerostin levels. E treatment of postmenopausal women (n=17) for 4 weeks led to a 27% decrease in serum sclerostin levels [versus +1% in controls (n=18), p<.001]. Similarly, in 59 elderly men, we eliminated endogenous E and T production and studied them under conditions of physiologic T and E replacement, and then following withdrawal of T or E, we found that E, but not T, prevented increases in sclerostin levels following induction of sex steroid deficiency. In both sexes, changes in sclerostin levels correlated with changes in bone-resorption, but not bone-formation, markers (r=0.62, p<.001, and r=0.33, p=.009, for correlations with changes in serum C-terminal telopeptide of type 1 collagen in the women and men, respectively). Our studies thus establish that in humans, circulating sclerostin levels are reduced by E but not by T. Moreover, consistent with recent data indicating important effects of Wnts on osteoclastic cells, our findings suggest that in humans, changes in sclerostin production may contribute to effects of E on bone resorption. © 2011 American Society for Bone and Mineral Research. Sex steroids are important regulators of bone turnover, but the mechanisms of their effects on bone remain unclear. Sclerostin is an inhibitor of Wnt signaling, and circulating estrogen (E) levels are inversely associated with sclerostin levels in postmenopausal women. To directly test for sex steroid regulation of sclerostin levels, we examined effects of E treatment of postmenopausal women or selective withdrawal of E versus testosterone (T) in elderly men on circulating sclerostin levels. E treatment of postmenopausal women (n = 17) for 4 weeks led to a 27% decrease in serum sclerostin levels [versus +1% in controls (n = 18), p < .001]. Similarly, in 59 elderly men, we eliminated endogenous E and T production and studied them under conditions of physiologic T and E replacement, and then following withdrawal of Tor E, we found that E, but notT, prevented increases in sclerostin levels following induction of sex steroid deficiency. In both sexes, changes in sclerostin levels correlated with changes in bone-resorption, but not bone-formation, markers (r = 0.62, p < .001, and r = 0.33, p = .009, for correlations with changes in serum C-terminal telopeptide of type 1 collagen in the women and men, respectively). Our studies thus establish that in humans, circulating sclerostin levels are reduced by E but not by T. Moreover, consistent with recent data indicating important effects of Wnts on osteoclastic cells, our findings suggest that in humans, changes in sclerostin production may contribute to effects of E on bone resorption. Sex steroids are important regulators of bone turnover, but the mechanisms of their effects on bone remain unclear. Sclerostin is an inhibitor of Wnt signaling, and circulating estrogen (E) levels are inversely associated with sclerostin levels in postmenopausal women. To directly test for sex steroid regulation of sclerostin levels, we examined effects of E treatment of postmenopausal women or selective withdrawal of E versus testosterone (T) in elderly men on circulating sclerostin levels. E treatment of postmenopausal women (n=17) for 4 weeks led to a 27% decrease in serum sclerostin levels [versus +1% in controls (n=18), p<.001]. Similarly, in 59 elderly men, we eliminated endogenous E and T production and studied them under conditions of physiologic T and E replacement, and then following withdrawal of T or E, we found that E, but not T, prevented increases in sclerostin levels following induction of sex steroid deficiency. In both sexes, changes in sclerostin levels correlated with changes in bone-resorption, but not bone-formation, markers (r=0.62, p<.001, and r=0.33, p=.009, for correlations with changes in serum C-terminal telopeptide of type 1 collagen in the women and men, respectively). Our studies thus establish that in humans, circulating sclerostin levels are reduced by E but not by T. Moreover, consistent with recent data indicating important effects of Wnts on osteoclastic cells, our findings suggest that in humans, changes in sclerostin production may contribute to effects of E on bone resorption. copyright 2011 American Society for Bone and Mineral Research. Sex steroids are important regulators of bone turnover, but the mechanisms of their effects on bone remain unclear. Sclerostin is an inhibitor of Wnt signaling, and circulating estrogen (E) levels are inversely associated with sclerostin levels in postmenopausal women. To directly test for sex steroid regulation of sclerostin levels, we examined effects of E treatment of postmenopausal women or selective withdrawal of E versus testosterone (T) in elderly men on circulating sclerostin levels. E treatment of postmenopausal women ( n = 17) for 4 weeks led to a 27% decrease in serum sclerostin levels [versus +1% in controls ( n = 18), p < .001]. Similarly, in 59 elderly men, we eliminated endogenous E and T production and studied them under conditions of physiologic T and E replacement, and then following withdrawal of T or E, we found that E, but not T, prevented increases in sclerostin levels following induction of sex steroid deficiency. In both sexes, changes in sclerostin levels correlated with changes in bone-resorption, but not bone-formation, markers ( r = 0.62, p < .001, and r = 0.33, p = .009, for correlations with changes in serum C-terminal telopeptide of type 1 collagen in the women and men, respectively). Our studies thus establish that in humans, circulating sclerostin levels are reduced by E but not by T. Moreover, consistent with recent data indicating important effects of Wnts on osteoclastic cells, our findings suggest that in humans, changes in sclerostin production may contribute to effects of E on bone resorption. © 2011 American Society for Bone and Mineral Research. Abstract Sex steroids are important regulators of bone turnover, but the mechanisms of their effects on bone remain unclear. Sclerostin is an inhibitor of Wnt signaling, and circulating estrogen (E) levels are inversely associated with sclerostin levels in postmenopausal women. To directly test for sex steroid regulation of sclerostin levels, we examined effects of E treatment of postmenopausal women or selective withdrawal of E versus testosterone (T) in elderly men on circulating sclerostin levels. E treatment of postmenopausal women (n = 17) for 4 weeks led to a 27% decrease in serum sclerostin levels [versus +1% in controls (n = 18), p < .001]. Similarly, in 59 elderly men, we eliminated endogenous E and T production and studied them under conditions of physiologic T and E replacement, and then following withdrawal of T or E, we found that E, but not T, prevented increases in sclerostin levels following induction of sex steroid deficiency. In both sexes, changes in sclerostin levels correlated with changes in bone-resorption, but not bone-formation, markers (r = 0.62, p < .001, and r = 0.33, p = .009, for correlations with changes in serum C-terminal telopeptide of type 1 collagen in the women and men, respectively). Our studies thus establish that in humans, circulating sclerostin levels are reduced by E but not by T. Moreover, consistent with recent data indicating important effects of Wnts on osteoclastic cells, our findings suggest that in humans, changes in sclerostin production may contribute to effects of E on bone resorption. © 2011 American Society for Bone and Mineral Research. Sex steroids are important regulators of bone turnover, but the mechanisms of their effects on bone remain unclear. Sclerostin is an inhibitor of Wnt signaling, and circulating estrogen (E) levels are inversely associated with sclerostin levels in postmenopausal women. To directly test for sex steroid regulation of sclerostin levels, we examined effects of E treatment of postmenopausal women or selective withdrawal of E versus testosterone (T) in elderly men on circulating sclerostin levels. E treatment of postmenopausal women (n = 17) for 4 weeks led to a 27% decrease in serum sclerostin levels [versus +1% in controls (n = 18), p < .001]. Similarly, in 59 elderly men, we eliminated endogenous E and T production and studied them under conditions of physiologic T and E replacement, and then following withdrawal of T or E, we found that E, but not T, prevented increases in sclerostin levels following induction of sex steroid deficiency. In both sexes, changes in sclerostin levels correlated with changes in bone-resorption, but not bone-formation, markers (r = 0.62, p < .001, and r = 0.33, p = .009, for correlations with changes in serum C-terminal telopeptide of type 1 collagen in the women and men, respectively). Our studies thus establish that in humans, circulating sclerostin levels are reduced by E but not by T. Moreover, consistent with recent data indicating important effects of Wnts on osteoclastic cells, our findings suggest that in humans, changes in sclerostin production may contribute to effects of E on bone resorption. |
Author | McCready, Louise Mödder, Ulrike IL Clowes, Jackie A Hoey, Kelley Riggs, B Lawrence Khosla, Sundeep Peterson, James M Oursler, Merry Jo |
AuthorAffiliation | Endocrine Research Unit, College of Medicine, Mayo Clinic Rochester, MN, USA |
AuthorAffiliation_xml | – name: Endocrine Research Unit, College of Medicine, Mayo Clinic Rochester, MN, USA |
Author_xml | – sequence: 1 givenname: Ulrike IL surname: Mödder fullname: Mödder, Ulrike IL – sequence: 2 givenname: Jackie A surname: Clowes fullname: Clowes, Jackie A – sequence: 3 givenname: Kelley surname: Hoey fullname: Hoey, Kelley – sequence: 4 givenname: James M surname: Peterson fullname: Peterson, James M – sequence: 5 givenname: Louise surname: McCready fullname: McCready, Louise – sequence: 6 givenname: Merry Jo surname: Oursler fullname: Oursler, Merry Jo – sequence: 7 givenname: B Lawrence surname: Riggs fullname: Riggs, B Lawrence – sequence: 8 givenname: Sundeep surname: Khosla fullname: Khosla, Sundeep email: khosla.sundeep@mayo.edu |
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Cites_doi | 10.1093/hmg/10.5.537 10.1359/jbmr.1998.13.7.1124 10.7326/0003-4819-117-1-1 10.1111/j.1365-2141.2009.08009.x 10.1172/JCI28551 10.1210/er.2007-0014 10.1002/ajmg.10401 10.1073/pnas.0505575102 10.1016/j.cell.2005.05.008 10.1359/jbmr.080216 10.1359/jbmr.081206 10.1359/jbmr.071212 10.1210/jc.2002-021036 10.1016/j.bbrc.2004.11.097 10.1182/blood.V114.22.425.425 10.1210/jc.2007-2397 10.1359/jbmr.070207 10.1210/jc.2009-2283 10.1677/joe.0.1420119 10.1016/j.devcel.2005.02.017 10.1210/jc.2010-0720 10.1242/jcs.02883 10.1210/en.2007-0270 10.1056/NEJM199808273390905 10.1074/jbc.M703224200 10.1007/s00198-008-0731-y 10.2353/ajpath.2009.080484 10.1136/jmg.39.2.91 10.1172/JCI1039 10.1056/NEJM199410203311604 10.1086/318811 10.1016/j.bone.2009.03.676 10.1172/JCI10942 10.1056/NEJM199707103370204 10.1210/edrv.23.3.0465 |
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Copyright | Copyright © 2011 American Society for Bone and Mineral Research 2015 INIST-CNRS 2011 American Society for Bone and Mineral Research. Copyright © 2011 American Society for Bone and Mineral Research 2011 |
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Keywords | Human Steroid SCLEROSTIN Androgen Estrogen Sex Ovarian hormone Osteoarticular system Testosterone Vertebrata Mammalia Turnover Female Testicular hormone Bone Sex steroid hormone BONE TURNOVER |
Language | English |
License | CC BY 4.0 2011 American Society for Bone and Mineral Research. Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
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PublicationTitle | Journal of bone and mineral research |
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References | 2009; 45 2007; 148 2002; 39 2009; 24 1994; 331 1997; 337 2006; 119 2009; 20 2007; 282 2002; 110 2000; 21 1998; 339 2007 2009; 174 2006; 116 2001; 68 2008; 93 2009; 114 2005; 122 2005; 102 2002; 23 2000; 106 2008; 29 1994; 142 2005; 8 1992; 117 2005; 328 2008; 23 2007; 22 1998; 101 1998; 12 2010; 95 2009; 148 2003; 88 1998; 13 2001; 10 7964270 - J Endocrinol. 1994 Jul;142(1):119-25 16087863 - Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11651-6 16009131 - Cell. 2005 Jul 15;122(1):33-43 11836356 - J Med Genet. 2002 Feb;39(2):91-7 15866165 - Dev Cell. 2005 May;8(5):751-64 12116252 - Am J Med Genet. 2002 Jun 15;110(2):144-52 18769961 - Osteoporos Int. 2009 May;20(5):761-9 17295604 - J Bone Miner Res. 2007 May;22(5):724-9 9576759 - J Clin Invest. 1998 May 1;101(9):1942-50 18086006 - J Bone Miner Res. 2008 May;23(5):705-14 12519853 - J Clin Endocrinol Metab. 2003 Jan;88(1):204-10 17395698 - Endocrinology. 2007 Jun;148(6):2635-43 20631014 - J Clin Endocrinol Metab. 2010 Nov;95(11):5056-62 18057140 - Endocr Rev. 2008 Apr;29(2):155-92 11179006 - Am J Hum Genet. 2001 Mar;68(3):577-89 11181578 - Hum Mol Genet. 2001 Mar 1;10(5):537-43 9718379 - N Engl J Med. 1998 Aug 27;339(9):599-603 16522681 - J Cell Sci. 2006 Apr 1;119(Pt 7):1283-96 17491024 - J Biol Chem. 2007 Jul 13;282(28):20715-27 19049336 - J Bone Miner Res. 2009 Apr;24(4):578-88 9661076 - J Bone Miner Res. 1998 Jul;13(7):1124-33 18269310 - J Bone Miner Res. 2008 Jun;23(6):860-9 11120762 - J Clin Invest. 2000 Dec;106(12):1553-60 9211678 - N Engl J Med. 1997 Jul 10;337(2):91-5 18505767 - J Clin Endocrinol Metab. 2008 Aug;93(8):3088-96 8090165 - N Engl J Med. 1994 Oct 20;331(16):1056-61 15694402 - Biochem Biophys Res Commun. 2005 Mar 18;328(3):688-96 12050121 - Endocr Rev. 2002 Jun;23(3):279-302 19371798 - Bone. 2009 Aug;45(2):289-94 19095956 - Am J Pathol. 2009 Jan;174(1):123-35 1534476 - Ann Intern Med. 1992 Jul 1;117(1):1-9 19961481 - Br J Haematol. 2010 Mar;148(5):726-38 20156921 - J Clin Endocrinol Metab. 2010 Apr;95(4):1991-7 9817600 - Mol Endocrinol. 1998 Nov;12(11):1749-63 10782361 - Endocr Rev. 2000 Apr;21(2):115-37 16670761 - J Clin Invest. 2006 May;116(5):1202-9 Charatcharoenwitthaya (2024020318042460400_bib4) 2007; 22 Leder (2024020318042460400_bib9) 2003; 88 Li (2024020318042460400_bib18) 2008; 23 Huang (2024020318042460400_bib24) 2009; 45 Smith (2024020318042460400_bib29) 2008; 93 Krishnan (2024020318042460400_bib12) 2006; 116 Armstrong (2024020318042460400_bib13) 2007; 282 Riggs (2024020318042460400_bib2) 2002; 23 Terpos (2024020318042460400_bib22) 2009; 114 Carroll (2024020318042460400_bib27) 2005; 122 Bilezikian (2024020318042460400_bib31) 1998; 339 Baron (2024020318042460400_bib11) 2007; 148 Lufkin (2024020318042460400_bib1) 1992; 117 Staehling-Hampton (2024020318042460400_bib16) 2002; 110 Jilka (2024020318042460400_bib3) 1998; 101 Balemans (2024020318042460400_bib17) 2002; 39 Clowes (2024020318042460400_bib21) 2009; 20 Carani (2024020318042460400_bib30) 1997; 337 Smith (2024020318042460400_bib28) 1994; 331 Syed (2024020318042460400_bib32) 2005; 328 Manolagas (2024020318042460400_bib7) 2000; 21 Drake (2024020318042460400_bib33) 2010; 95 Sanyal (2024020318042460400_bib10) 2008; 23 Lean (2024020318042460400_bib6) 1994; 142 Glass (2024020318042460400_bib23) 2005; 8 Boruk (2024020318042460400_bib25) 1998; 12 Spencer (2024020318042460400_bib36) 2006; 119 Balemans (2024020318042460400_bib15) 2001; 10 Kearns (2024020318042460400_bib35) 2008; 29 Falahati-Nini (2024020318042460400_bib8) 2000; 106 Qiang (2024020318042460400_bib38) 2009; 148 Li (2024020318042460400_bib19) 2009; 24 Padhi (2024020318042460400_bib34) 2007 Hannon (2024020318042460400_bib5) 1998; 13 Mirza (2024020318042460400_bib20) 2010; 95 Laganiere (2024020318042460400_bib26) 2005; 102 Brunkow (2024020318042460400_bib14) 2001; 68 Modarresi (2024020318042460400_bib37) 2009; 174 |
References_xml | – volume: 68 start-page: 577 year: 2001 end-page: 589 article-title: Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot‐containing protein publication-title: Am J Hum Genet. – volume: 23 start-page: 860 year: 2008 end-page: 869 article-title: Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength publication-title: J Bone Miner Res. – volume: 29 start-page: 155 year: 2008 end-page: 192 article-title: Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease publication-title: Endocr Rev. – volume: 148 start-page: 726 year: 2009 end-page: 738 article-title: Characterization of Wnt/beta‐catenin signaling in osteoclasts in multiple myeloma publication-title: Br J Haematol. – volume: 142 start-page: 119 year: 1994 end-page: 125 article-title: The rate of cancellous bone formation falls immediately after ovariectomy in the rat publication-title: J Endocrinol. – volume: 337 start-page: 91 year: 1997 end-page: 95 article-title: Effect of testosterone and estradiol in a man with aromatase deficiency publication-title: N Engl J Med. – volume: 116 start-page: 1202 year: 2006 end-page: 1209 article-title: Regulation of bone mass by Wnt signaling publication-title: J Clin Invest. – volume: 339 start-page: 599 year: 1998 end-page: 603 article-title: Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency publication-title: N Engl J Med. – volume: 39 start-page: 91 year: 2002 end-page: 97 article-title: Identification of a 52kb deletion downstream of the SOST gene in patients with van Buchem disease publication-title: J Med Genet. – volume: 45 start-page: 289 year: 2009 end-page: 294 article-title: The ‐9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPalpha and FOXA1 binding is associated with osteoporosis publication-title: Bone. – volume: 119 start-page: 1283 year: 2006 end-page: 1296 article-title: Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkappB ligand and inhibits osteoclastogenesis in vitro publication-title: J Cell Sci. – volume: 282 start-page: 20715 year: 2007 end-page: 20727 article-title: WNT/B‐Catenin signaling is a component of osteoblastic bone cells' early responses to load‐bearing, and requires estrogen receptor a publication-title: J Biol Chem. – volume: 10 start-page: 537 year: 2001 end-page: 543 article-title: Increase bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST) publication-title: Hum Mol Genet. – volume: 117 start-page: 1 year: 1992 end-page: 9 article-title: Treatment of postmenopausal osteoporosis with transdermal estrogen publication-title: Ann Intern Med. – volume: 102 start-page: 11651 year: 2005 end-page: 11656 article-title: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response publication-title: Proc Natl Acad Sci USA. – volume: 331 start-page: 1056 year: 1994 end-page: 1061 article-title: Estrogen resistance caused by a mutation in the estrogen‐receptor gene in a man publication-title: N Engl J Med. – volume: 122 start-page: 33 year: 2005 end-page: 43 article-title: Chromosome‐wide mapping of estrogen receptor binding reveals long‐range regulation requiring the forkhead protein FoxA1 publication-title: Cell. – volume: 12 start-page: 1749 year: 1998 end-page: 1763 article-title: AF‐2‐dependent potentiation of CCAAT enhancer binding protein beta‐mediated transcriptional activation by glucocorticoid receptor publication-title: Mol Endocrinol. – volume: 23 start-page: 705 year: 2008 end-page: 714 article-title: Regulation of bone turnover by sex steroids in men publication-title: J Bone Miner Res. – volume: 95 start-page: 5056 year: 2010 end-page: 5062 article-title: Effects of parathyroid hormone treatment on circulating sclerostin levels in postmenopausal women publication-title: J Clin Endocrinol Metab. – volume: 24 start-page: 578 year: 2009 end-page: 588 article-title: Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis publication-title: J Bone Miner Res. – volume: 328 start-page: 688 year: 2005 end-page: 696 article-title: Mechanisms of sex steroid effects on bone publication-title: Biochem Biophys Res Commun. – volume: 93 start-page: 3088 year: 2008 end-page: 3096 article-title: Impact on bone of an estrogen receptor‐alpha gene loss of function mutation publication-title: J Clin Endocrinol Metab. – volume: 110 start-page: 144 year: 2002 end-page: 152 article-title: A 52‐kb deletion in the SOST‐MEOX1 intergenic region on 17q12‐q21 is associated with van Buchem disease in the Dutch population publication-title: Am J Med Genet. – volume: 13 start-page: 1124 year: 1998 end-page: 1133 article-title: Response of biochemical markers of bone turnover to hormone replacement therapy: impact of biological variability publication-title: J Bone Miner Res. – volume: 106 start-page: 1553 year: 2000 end-page: 1560 article-title: Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men publication-title: J Clin Invest. – volume: 23 start-page: 279 year: 2002 end-page: 302 article-title: Sex steroids and the construction and conservation of the adult skeleton publication-title: Endocr Rev. – volume: 22 start-page: 724 year: 2007 end-page: 729 article-title: Effect of blockade of TNF‐α and interleukin 1 action on bone resorption in early postmenopausal women publication-title: J Bone Miner Res. – volume: 88 start-page: 204 year: 2003 end-page: 210 article-title: Differential effects of androgens and estrogens on bone turnover in normal men publication-title: J Clin Endocrinol Metab. – volume: 8 start-page: 751 year: 2005 end-page: 764 article-title: Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation publication-title: Dev Cell. – volume: 21 start-page: 115 year: 2000 end-page: 137 article-title: Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis publication-title: Endocr Rev. – volume: 114 year: 2009 article-title: High serum sclerostin correlates with advanced stage, increased bone resorption, reducted osteoblast function, and poor survival in newly‐diagnosed patients with multiple myeloma publication-title: Blood. – year: 2007 article-title: Anti‐sclerostin antibody increases markers of bone formation in healthy postmenopausal women publication-title: American Society for Bone and Mineral Research Annual Meeting. – volume: 95 start-page: 1991 year: 2010 end-page: 1997 article-title: Serum sclerostin levels negatively correlate with parathyroid hormone levels and free estrogen index in postmenopausal women publication-title: J Clin Endocrinol Metab. – volume: 174 start-page: 123 year: 2009 end-page: 135 article-title: WNT/beta‐catenin signaling is involved in regulation of osteoclast differentiation by human immunodeficiency virus protease inhibitor ritonavir: relationship to human immunodeficiency virus‐linked bone mineral loss publication-title: Am J Pathol. – volume: 148 start-page: 2635 year: 2007 end-page: 2643 article-title: Targeting the Wnt/beta‐catenin pathway to regulate bone formation in the adult skeleton publication-title: Endocrinology. – volume: 101 start-page: 1942 year: 1998 end-page: 1950 article-title: Loss of estrogen upregulates osteoblastogenesis in the murine bone marrow publication-title: J Clin Invest. – volume: 20 start-page: 761 year: 2009 end-page: 769 article-title: Estrogen action on bone marrow osteoclast lineage cells of postmenopausal women in vivo publication-title: Osteoporos Int. – volume: 10 start-page: 537 year: 2001 ident: 2024020318042460400_bib15 article-title: Increase bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST) publication-title: Hum Mol Genet. doi: 10.1093/hmg/10.5.537 contributor: fullname: Balemans – volume: 13 start-page: 1124 year: 1998 ident: 2024020318042460400_bib5 article-title: Response of biochemical markers of bone turnover to hormone replacement therapy: impact of biological variability publication-title: J Bone Miner Res. doi: 10.1359/jbmr.1998.13.7.1124 contributor: fullname: Hannon – volume: 21 start-page: 115 year: 2000 ident: 2024020318042460400_bib7 article-title: Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis publication-title: Endocr Rev. contributor: fullname: Manolagas – volume: 117 start-page: 1 year: 1992 ident: 2024020318042460400_bib1 article-title: Treatment of postmenopausal osteoporosis with transdermal estrogen publication-title: Ann Intern Med. doi: 10.7326/0003-4819-117-1-1 contributor: fullname: Lufkin – volume: 148 start-page: 726 year: 2009 ident: 2024020318042460400_bib38 article-title: Characterization of Wnt/beta-catenin signaling in osteoclasts in multiple myeloma publication-title: Br J Haematol. doi: 10.1111/j.1365-2141.2009.08009.x contributor: fullname: Qiang – volume: 116 start-page: 1202 year: 2006 ident: 2024020318042460400_bib12 article-title: Regulation of bone mass by Wnt signaling publication-title: J Clin Invest. doi: 10.1172/JCI28551 contributor: fullname: Krishnan – volume: 29 start-page: 155 year: 2008 ident: 2024020318042460400_bib35 article-title: Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease publication-title: Endocr Rev. doi: 10.1210/er.2007-0014 contributor: fullname: Kearns – volume: 110 start-page: 144 year: 2002 ident: 2024020318042460400_bib16 article-title: A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population publication-title: Am J Med Genet. doi: 10.1002/ajmg.10401 contributor: fullname: Staehling-Hampton – volume: 102 start-page: 11651 year: 2005 ident: 2024020318042460400_bib26 article-title: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response publication-title: Proc Natl Acad Sci USA. doi: 10.1073/pnas.0505575102 contributor: fullname: Laganiere – volume: 122 start-page: 33 year: 2005 ident: 2024020318042460400_bib27 article-title: Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1 publication-title: Cell. doi: 10.1016/j.cell.2005.05.008 contributor: fullname: Carroll – volume: 23 start-page: 860 year: 2008 ident: 2024020318042460400_bib18 article-title: Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength publication-title: J Bone Miner Res. doi: 10.1359/jbmr.080216 contributor: fullname: Li – volume: 24 start-page: 578 year: 2009 ident: 2024020318042460400_bib19 article-title: Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis publication-title: J Bone Miner Res. doi: 10.1359/jbmr.081206 contributor: fullname: Li – volume: 23 start-page: 705 year: 2008 ident: 2024020318042460400_bib10 article-title: Regulation of bone turnover by sex steroids in men publication-title: J Bone Miner Res. doi: 10.1359/jbmr.071212 contributor: fullname: Sanyal – volume: 88 start-page: 204 year: 2003 ident: 2024020318042460400_bib9 article-title: Differential effects of androgens and estrogens on bone turnover in normal men publication-title: J Clin Endocrinol Metab. doi: 10.1210/jc.2002-021036 contributor: fullname: Leder – year: 2007 ident: 2024020318042460400_bib34 article-title: Anti-sclerostin antibody increases markers of bone formation in healthy postmenopausal women publication-title: American Society for Bone and Mineral Research Annual Meeting. contributor: fullname: Padhi – volume: 328 start-page: 688 year: 2005 ident: 2024020318042460400_bib32 article-title: Mechanisms of sex steroid effects on bone publication-title: Biochem Biophys Res Commun. doi: 10.1016/j.bbrc.2004.11.097 contributor: fullname: Syed – volume: 114 year: 2009 ident: 2024020318042460400_bib22 article-title: High serum sclerostin correlates with advanced stage, increased bone resorption, reducted osteoblast function, and poor survival in newly-diagnosed patients with multiple myeloma publication-title: Blood. doi: 10.1182/blood.V114.22.425.425 contributor: fullname: Terpos – volume: 93 start-page: 3088 year: 2008 ident: 2024020318042460400_bib29 article-title: Impact on bone of an estrogen receptor-alpha gene loss of function mutation publication-title: J Clin Endocrinol Metab. doi: 10.1210/jc.2007-2397 contributor: fullname: Smith – volume: 22 start-page: 724 year: 2007 ident: 2024020318042460400_bib4 article-title: Effect of blockade of TNF-α and interleukin 1 action on bone resorption in early postmenopausal women publication-title: J Bone Miner Res. doi: 10.1359/jbmr.070207 contributor: fullname: Charatcharoenwitthaya – volume: 95 start-page: 1991 year: 2010 ident: 2024020318042460400_bib20 article-title: Serum sclerostin levels negatively correlate with parathyroid hormone levels and free estrogen index in postmenopausal women publication-title: J Clin Endocrinol Metab. doi: 10.1210/jc.2009-2283 contributor: fullname: Mirza – volume: 142 start-page: 119 year: 1994 ident: 2024020318042460400_bib6 article-title: The rate of cancellous bone formation falls immediately after ovariectomy in the rat publication-title: J Endocrinol. doi: 10.1677/joe.0.1420119 contributor: fullname: Lean – volume: 8 start-page: 751 year: 2005 ident: 2024020318042460400_bib23 article-title: Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation publication-title: Dev Cell. doi: 10.1016/j.devcel.2005.02.017 contributor: fullname: Glass – volume: 95 start-page: 5056 year: 2010 ident: 2024020318042460400_bib33 article-title: Effects of parathyroid hormone treatment on circulating sclerostin levels in postmenopausal women publication-title: J Clin Endocrinol Metab. doi: 10.1210/jc.2010-0720 contributor: fullname: Drake – volume: 119 start-page: 1283 year: 2006 ident: 2024020318042460400_bib36 article-title: Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkappB ligand and inhibits osteoclastogenesis in vitro publication-title: J Cell Sci. doi: 10.1242/jcs.02883 contributor: fullname: Spencer – volume: 148 start-page: 2635 year: 2007 ident: 2024020318042460400_bib11 article-title: Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton publication-title: Endocrinology. doi: 10.1210/en.2007-0270 contributor: fullname: Baron – volume: 339 start-page: 599 year: 1998 ident: 2024020318042460400_bib31 article-title: Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency publication-title: N Engl J Med. doi: 10.1056/NEJM199808273390905 contributor: fullname: Bilezikian – volume: 282 start-page: 20715 year: 2007 ident: 2024020318042460400_bib13 article-title: WNT/B-Catenin signaling is a component of osteoblastic bone cells' early responses to load-bearing, and requires estrogen receptor a publication-title: J Biol Chem. doi: 10.1074/jbc.M703224200 contributor: fullname: Armstrong – volume: 12 start-page: 1749 year: 1998 ident: 2024020318042460400_bib25 article-title: AF-2-dependent potentiation of CCAAT enhancer binding protein beta-mediated transcriptional activation by glucocorticoid receptor publication-title: Mol Endocrinol. contributor: fullname: Boruk – volume: 20 start-page: 761 year: 2009 ident: 2024020318042460400_bib21 article-title: Estrogen action on bone marrow osteoclast lineage cells of postmenopausal women in vivo publication-title: Osteoporos Int. doi: 10.1007/s00198-008-0731-y contributor: fullname: Clowes – volume: 174 start-page: 123 year: 2009 ident: 2024020318042460400_bib37 article-title: WNT/beta-catenin signaling is involved in regulation of osteoclast differentiation by human immunodeficiency virus protease inhibitor ritonavir: relationship to human immunodeficiency virus-linked bone mineral loss publication-title: Am J Pathol. doi: 10.2353/ajpath.2009.080484 contributor: fullname: Modarresi – volume: 39 start-page: 91 year: 2002 ident: 2024020318042460400_bib17 article-title: Identification of a 52kb deletion downstream of the SOST gene in patients with van Buchem disease publication-title: J Med Genet. doi: 10.1136/jmg.39.2.91 contributor: fullname: Balemans – volume: 101 start-page: 1942 year: 1998 ident: 2024020318042460400_bib3 article-title: Loss of estrogen upregulates osteoblastogenesis in the murine bone marrow publication-title: J Clin Invest. doi: 10.1172/JCI1039 contributor: fullname: Jilka – volume: 331 start-page: 1056 year: 1994 ident: 2024020318042460400_bib28 article-title: Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man publication-title: N Engl J Med. doi: 10.1056/NEJM199410203311604 contributor: fullname: Smith – volume: 68 start-page: 577 year: 2001 ident: 2024020318042460400_bib14 article-title: Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein publication-title: Am J Hum Genet. doi: 10.1086/318811 contributor: fullname: Brunkow – volume: 45 start-page: 289 year: 2009 ident: 2024020318042460400_bib24 article-title: The -9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPalpha and FOXA1 binding is associated with osteoporosis publication-title: Bone. doi: 10.1016/j.bone.2009.03.676 contributor: fullname: Huang – volume: 106 start-page: 1553 year: 2000 ident: 2024020318042460400_bib8 article-title: Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men publication-title: J Clin Invest. doi: 10.1172/JCI10942 contributor: fullname: Falahati-Nini – volume: 337 start-page: 91 year: 1997 ident: 2024020318042460400_bib30 article-title: Effect of testosterone and estradiol in a man with aromatase deficiency publication-title: N Engl J Med. doi: 10.1056/NEJM199707103370204 contributor: fullname: Carani – volume: 23 start-page: 279 year: 2002 ident: 2024020318042460400_bib2 article-title: Sex steroids and the construction and conservation of the adult skeleton publication-title: Endocr Rev. doi: 10.1210/edrv.23.3.0465 contributor: fullname: Riggs |
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Snippet | Sex steroids are important regulators of bone turnover, but the mechanisms of their effects on bone remain unclear. Sclerostin is an inhibitor of Wnt... Abstract Sex steroids are important regulators of bone turnover, but the mechanisms of their effects on bone remain unclear. Sclerostin is an inhibitor of Wnt... |
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SubjectTerms | Adult Aged Aged, 80 and over Analysis of Variance Biological and medical sciences Biomarkers - metabolism Bone Morphogenetic Proteins - blood Bone Remodeling - drug effects BONE TURNOVER Collagen Type I - blood Estradiol - administration & dosage Estradiol - pharmacology ESTROGEN Female Fundamental and applied biological sciences. Psychology Genetic Markers Humans Male Middle Aged Original Osteoprotegerin - blood Peptides - blood SCLEROSTIN Skeleton and joints TESTOSTERONE Testosterone - administration & dosage Testosterone - pharmacology Vertebrates: osteoarticular system, musculoskeletal system |
Title | Regulation of circulating sclerostin levels by sex steroids in women and in men |
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