Characteristics of ACh‐induced hyperpolarization and relaxation in rabbit jugular vein

• Published in: British journal of pharmacology Vol. 167; no. 3; pp. 682 - 696
• Main Authors: Itoh, Takeo, Maekawa, Takashi, Shibayama, Yasushi
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2012; Nature Publishing Group
• Subjects: Acetylcholine - administration & dosage; Acetylcholine - pharmacology; ACh; Animals; basal NO release; Biological and medical sciences; Calcium - metabolism; calcium‐activated K+ channels; Dose-Response Relationship, Drug; EDHF; endothelial cell hyperpolarization; Endothelium; Endothelium, Vascular - drug effects; Endothelium, Vascular - metabolism; Jugular Veins - drug effects; Jugular Veins - metabolism; Male; Medical sciences; Myocytes, Smooth Muscle - drug effects; Myocytes, Smooth Muscle - metabolism; Nitric Oxide - metabolism; Pharmacology. Drug treatments; Potassium Channels, Calcium-Activated - drug effects; Potassium Channels, Calcium-Activated - metabolism; Potassium Channels, Voltage-Gated - metabolism; rabbit jugular vein; Rabbits; Research Papers; smooth muscle cell hyperpolarization; Vasodilation - drug effects; Vasodilator Agents - administration & dosage; Vasodilator Agents - pharmacology; Veins & arteries; voltage‐dependent K+ channels; NO; Endothelial cell; smooth muscle cell hyperpolarization; Calcium; ACh; basal NO release; endothelial cell hyperpolarization; Rabbit; Smooth muscle; Ionic channel; Inorganic element; Blood vessel; Vein; Release; Lagomorpha; In vitro; Endothelium; Vertebrata; Mammalia; channels; Animal; voltage-dependent K; Circulatory system; calcium-activated K; Potassium; EDHF; Hyperpolarization; rabbit jugular vein

BACKGROUND AND PURPOSE The roles played by endothelium‐derived NO and prostacyclin and by endothelial cell hyperpolarization in ACh‐induced relaxation have been well characterized in arteries. However, the mechanisms underlying ACh‐induced relaxation in veins remain to be fully clarified. EXPERIMENT...