Relation of age, gender, and bone mass to circulating sclerostin levels in women and men

• Published in: Journal of bone and mineral research Vol. 26; no. 2; pp. 373 - 379
• Main Authors: Mödder, Ulrike I, Hoey, Kelley A, Amin, Shreyasee, McCready, Louise K, Achenbach, Sara J, Riggs, B Lawrence, Melton, L Joseph, Khosla, Sundeep
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.02.2011; Wiley; Wiley Subscription Services, Inc
• Subjects: Adult; Age; Age Factors; Aged; Aged, 80 and over; AGING; Biological and medical sciences; Bone and Bones - metabolism; Bone Density; Bone Morphogenetic Proteins - blood; Estrogens - metabolism; Female; Fundamental and applied biological sciences. Psychology; Genetic Markers; Hormone replacement therapy; Humans; Immunoassay - methods; Male; Middle Aged; Original; OSTEOPOROSIS; Postmenopause; SCLEROSTIN; Sex Factors; Skeleton and joints; Vertebrates: osteoarticular system, musculoskeletal system; Women; Human; SCLEROSTIN; Senescence; Ageing; Diseases of the osteoarticular system; Sex; AGING; Osteoarticular system; Osteoporosis; Vertebrata; Mammalia; Bone age; Female

Sclerostin is a potent inhibitor of Wnt signaling and bone formation. However, there is currently no information on the relation of circulating sclerostin levels to age, gender, or bone mass in humans. Thus we measured serum sclerostin levels in a population‐based sample of 362 women [123 premenopau...