Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity

• Published in: FEBS letters Vol. 587; no. 8; pp. 1106 - 1118
• Main Authors: Cao, Ping, Marek, Peter, Noor, Harris, Patsalo, Vadim, Tu, Ling-Hsien, Wang, Hui, Abedini, Andisheh, Raleigh, Daniel P.
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 17.04.2013
• Subjects: Amino Acid Sequence; Amylin; Amyloid; Amyloid - chemistry; Amyloid - genetics; Amyloid - metabolism; Biophysical Phenomena; Cell Survival; Humans; IAPP; Islet amyloid polypeptide; Islet Amyloid Polypeptide - chemistry; Islet Amyloid Polypeptide - genetics; Islet Amyloid Polypeptide - metabolism; Models, Molecular; Molecular Sequence Data; Mutation; Protein Structure, Secondary; Sequence Homology, Amino Acid; Type 2 diabetes; Type 2 diabetes; Amyloid; IAPP; Islet amyloid polypeptide; Amylin

Pancreatic islet amyloid is a characteristic feature of type 2 diabetes. The major protein component of islet amyloid is the polypeptide hormone known as islet amyloid polypeptide (IAPP, or amylin). IAPP is stored with insulin in the β-cell secretory granules and is released in response to the stimu...