Alterations in hippocampal somatostatin interneurons, GABAergic metabolism, and ASL perfusion in an aged male mouse model of POCD aggravated by sleep fragmentation

• Published in: Physiological reports Vol. 12; no. 23; pp. e70153 - n/a
• Main Authors: Li, Yun, Yu, Jiafeng, Yang, Ningzhi, Long, Siwen, Li, Yize, Zhao, Lina, Yu, Yonghao
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.12.2024; John Wiley and Sons Inc; Wiley
• Subjects: Aging; Aging - metabolism; Anesthesia; Animal cognition; Animals; Blood flow; Brain research; Carotid arteries; Cerebral blood flow; Cerebrovascular Circulation; Cognitive ability; Disease Models, Animal; gamma-Aminobutyric Acid - metabolism; Glutamate decarboxylase; Glutamate Decarboxylase - metabolism; Glutamic acid transporter; Hippocampus; Hippocampus - metabolism; Immunofluorescence; Interneurons; Interneurons - metabolism; Laboratory animals; magnetic resonance imaging; Male; Maze Learning; Memory; Metabolism; Mice; Mice, Inbred C57BL; Neuropeptide Y; Neuropeptide Y - metabolism; Original; Pattern recognition; Perfusion; POCD; Post traumatic stress disorder; Postoperative Cognitive Complications - etiology; Postoperative Cognitive Complications - metabolism; Regular Manuscript; Sleep; Sleep apnea; Sleep deprivation; Sleep Deprivation - metabolism; Sleep Deprivation - physiopathology; sleep fragmentation; Somatostatin; Somatostatin - metabolism; Spatial memory; Spin labeling; Spin Labels; Surgery; Vesicular Inhibitory Amino Acid Transport Proteins - metabolism; γ-Aminobutyric acid; Beijing China; China; magnetic resonance imaging; aging; hippocampus; POCD; sleep fragmentation; somatostatin

Sleep fragmentation (SF) is increasingly recognized as a contributing factor to postoperative cognitive dysfunction (POCD). Given the critical roles of somatostatin (SST) interneurons, associated gamma‐aminobutyric acid (GABA)ergic neurotransmitters, and hippocampal perfusion in sleep‐related cognit...