The orphan receptor GPR3 modulates the early phases of cocaine reinforcement

• Published in: British journal of pharmacology Vol. 167; no. 4; pp. 892 - 904
• Main Authors: Tourino, Clara, Valjent, Emmanuel, Ruiz‐Medina, Jessica, Herve, Denis, Ledent, Catherine, Valverde, Olga
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2012; Nature Publishing Group
• Subjects: adenylyl cyclase; Animal behavior; Animals; Behavior, Animal - drug effects; Biological and medical sciences; Cocaine; Cocaine - administration & dosage; Conditioning, Operant; Dopamine; Dopamine - metabolism; Drug addictions; Food; Gpr3 receptor‐deficient mice; intravenous self‐administration; Male; Medical sciences; Mice; Mice, Knockout; Motor Activity - drug effects; Nucleus Accumbens - drug effects; Nucleus Accumbens - metabolism; orphan receptor; Pharmacology. Drug treatments; Receptors, G-Protein-Coupled - physiology; reinforcement; Reinforcement (Psychology); Research Papers; Rodents; Self Administration; Toxicology; Intravenous administration; Enzyme; intravenous self-administration; Rodentia; Phosphorus-oxygen lyases; Lyases; Self administration; Ester; Adenylate cyclase; Vertebrata; Mammalia; Mouse; Animal; Reinforcement; adenylyl cyclase; Early; Cocaine; Drug of abuse; Gpr3 receptor-deficient mice; Orphan receptor; Biological receptor

BACKGROUND AND PURPOSE The modulatory activity of the orphan receptor GPR3 in the brain has been related to the control of emotional behaviours. Limbic structures that express GPR3 have been associated with the effects of drug abuse. EXPERIMENTAL APPROACH The role of GPR3 in different cocaine‐elicit...