氨磺必利合并舍曲林治疗老年期抑郁症的对照研究
目的探讨氨磺必利联合舍曲林对老年期抑郁症的治疗作用。方法采用随机开放对照研究,将符合《中国精神障碍分类与诊断标准（第3版）》（CCMD-3）的60例老年期抑郁症的患者随机分为研究组（氨磺必利联合舍曲林治疗组）与对照组（单纯舍曲林治疗组）,分别在治疗前及治疗后第2、4、6、8周末,采用汉密尔顿抑郁量表（HAMD）、临床总体印象量表（CGI-GI）评定疗效,采用Asberg抗抑郁剂副反应量表（SERS）评定两组的药物副反应。结果研究组HAMD评分在治疗后2周末、4周末、6周末以及8周末与治疗前比较差异有统计学意义（P〈0.05或0.01）;研究组CGI-GI总评分在治疗4周末、6周末以及8周末与治...
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| Published in | 四川精神卫生 Vol. 27; no. 5; pp. 410 - 412 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
214151,南京医科大学附属无锡精神卫生心
2014
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1007-3256 |
| DOI | 10.3969/j.issn.1007-3256.2014.05.007 |
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| Abstract | 目的探讨氨磺必利联合舍曲林对老年期抑郁症的治疗作用。方法采用随机开放对照研究,将符合《中国精神障碍分类与诊断标准（第3版）》（CCMD-3）的60例老年期抑郁症的患者随机分为研究组（氨磺必利联合舍曲林治疗组）与对照组（单纯舍曲林治疗组）,分别在治疗前及治疗后第2、4、6、8周末,采用汉密尔顿抑郁量表（HAMD）、临床总体印象量表（CGI-GI）评定疗效,采用Asberg抗抑郁剂副反应量表（SERS）评定两组的药物副反应。结果研究组HAMD评分在治疗后2周末、4周末、6周末以及8周末与治疗前比较差异有统计学意义（P〈0.05或0.01）;研究组CGI-GI总评分在治疗4周末、6周末以及8周末与治疗前比较差异有统计学意义（P均〈0.01）;治疗后第4、6、8周末,研究组CGI-GI总评分与对照组比较差异有统计学意义（P〈0.05或0.01）;对照组CGI-GI总评分在治疗8周末与治疗前比较差异有统计学意义（P〈0.01）。治疗后第8周末,对照组SERS评分与研究组比较[（5.4±2.8）分vs.（4.7±2.6）分],差异无统计学意义（P〉0.05）。结论氨磺必利联合舍曲林对老年期抑郁症的疗效优于单一应用舍曲林治疗,安全性好。 |
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| AbstractList | 目的探讨氨磺必利联合舍曲林对老年期抑郁症的治疗作用。方法采用随机开放对照研究,将符合《中国精神障碍分类与诊断标准（第3版）》（CCMD-3）的60例老年期抑郁症的患者随机分为研究组（氨磺必利联合舍曲林治疗组）与对照组（单纯舍曲林治疗组）,分别在治疗前及治疗后第2、4、6、8周末,采用汉密尔顿抑郁量表（HAMD）、临床总体印象量表（CGI-GI）评定疗效,采用Asberg抗抑郁剂副反应量表（SERS）评定两组的药物副反应。结果研究组HAMD评分在治疗后2周末、4周末、6周末以及8周末与治疗前比较差异有统计学意义（P〈0.05或0.01）;研究组CGI-GI总评分在治疗4周末、6周末以及8周末与治疗前比较差异有统计学意义（P均〈0.01）;治疗后第4、6、8周末,研究组CGI-GI总评分与对照组比较差异有统计学意义（P〈0.05或0.01）;对照组CGI-GI总评分在治疗8周末与治疗前比较差异有统计学意义（P〈0.01）。治疗后第8周末,对照组SERS评分与研究组比较[（5.4±2.8）分vs.（4.7±2.6）分],差异无统计学意义（P〉0.05）。结论氨磺必利联合舍曲林对老年期抑郁症的疗效优于单一应用舍曲林治疗,安全性好。 R749.4; 目的：探讨氨磺必利联合舍曲林对老年期抑郁症的治疗作用。方法采用随机开放对照研究，将符合《中国精神障碍分类与诊断标准(第3版)》(CCMD-3)的60例老年期抑郁症的患者随机分为研究组(氨磺必利联合舍曲林治疗组)与对照组(单纯舍曲林治疗组)，分别在治疗前及治疗后第2、4、6、8周末，采用汉密尔顿抑郁量表(HAMD)、临床总体印象量表(CGI-GI)评定疗效，采用Asberg抗抑郁剂副反应量表(SERS)评定两组的药物副反应。结果研究组HAMD评分在治疗后2周末、4周末、6周末以及8周末与治疗前比较差异有统计学意义( P<0.05或0.01)；研究组CGI-GI总评分在治疗4周末、6周末以及8周末与治疗前比较差异有统计学意义( P均<0.01)；治疗后第4、6、8周末，研究组CGI-GI总评分与对照组比较差异有统计学意义(P<0.05或0.01)；对照组CGI-GI总评分在治疗8周末与治疗前比较差异有统计学意义(P<0.01)。治疗后第8周末，对照组SERS评分与研究组比较[(5.4±2.8)分vs.(4.7±2.6)分]，差异无统计学意义(P>0.05)。结论氨磺必利联合舍曲林对老年期抑郁症的疗效优于单一应用舍曲林治疗，安全性好。 |
| Abstract_FL | Objective To study treatment effect of low dose Amisulpride combined Sertraline in the elderly depression. Meth-ods Employed open label extension study to randomized controlled trial, 60 patients ( no less than 60 years old) met with CCMD-3 for Depression criteria were divided into research group (treated with ow dose Amisulpride combined Sertraline ,n=30) and control group (treated with Sertraline,n=30) randomly. All subjects were assessed with Hamilton Rating Scale for Depression(HAMD),Clin-ical Global Impression(CGI-GI),Asberg Rating Scale for Side Effects before treatment and after 2,4,6 and 8 week treatment. Resu-lts There is significant HAMD difference between before treatment and after 2,4,6 and 8 week treatment in research group(P<0. 05 or 0. 01). There is significant CGI-GI difference between before treatment and after 4,6 and 8 weeks treatment in research group(P<0. 05 or 0. 01). There is significant CGI-GI difference between control group and after 4,6 and 8 weeks treatment in research group(P<0. 05 or 0. 01). There is significant CGI-GI difference between before and after 8 weeks treatment in control group(P<0. 01). There was no significant difference of score of Asberg Rating Scale for Side Effects between two groups(P>0. 05). Conclusion Treatment with low dose Amisulpride combined Sertraline for depression in the elderly is safe and treatment effect is better than that of Sertraline. |
| Author | 王志强 董昆仑 杨碧秀 陈新宇 王国强 |
| AuthorAffiliation | 南京医科大学附属无锡精神卫生心,214151 |
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| Author_FL | Chen Xin-yu WANG Zhi-qiang WANG Guo-qiang Dong Kun-lun YANG Bi-xiu |
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| Keywords | Depression in the elderly 舍曲林 老年期抑郁症 Treatment effect Amisulpride 安全性 氨磺必利 Safe Sertraline 疗效 |
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| Notes | 51-1457/R Objective To study treatment effect of low dose Amisulpride combined Sertraline in the elderly depression. Meth-ods Employed open label extension study to randomized controlled trial, 60 patients （ no less than 60 years old） met with CCMD-3 for Depression criteria were divided into research group （treated with ow dose Amisulpride combined Sertraline ,n=30） and control group （treated with Sertraline,n=30） randomly. All subjects were assessed with Hamilton Rating Scale for Depression（HAMD）,Clin-ical Global Impression（CGI-GI）,Asberg Rating Scale for Side Effects before treatment and after 2,4,6 and 8 week treatment. Resu-lts There is significant HAMD difference between before treatment and after 2,4,6 and 8 week treatment in research group（P〈0. 05 or 0. 01）. There is significant CGI-GI difference between before treatment and after 4,6 and 8 weeks treatment in research group（P〈0. 05 or 0. 01）. There is significant CGI-GI difference between control group and after 4,6 and 8 weeks treatment in research gro |
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| Publisher | 214151,南京医科大学附属无锡精神卫生心 |
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| SubjectTerms | 安全性 氨磺必利 疗效 老年期抑郁症 舍曲林 |
| Title | 氨磺必利合并舍曲林治疗老年期抑郁症的对照研究 |
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