湖北钟祥河南移民与湖北本地居民食管鳞状细胞癌组织中HPV感染的比较
R735.1%R73-31; 目的探讨湖北钟祥河南移民与湖北本地居民食管鳞状细胞癌组织中人乳头状瘤病毒(human papillomavirus,HPV)感染的情况.方法应用免疫组化S-P方法,检测82例食管癌组织中PV和HPV感染情况.以正常食管手术残端黏膜组织作正常对照.结果钟祥食管癌高发区、麻城地区、湖北省肿瘤医院标本中PV阳性感染率分别为75%、68.18%、72.5%.HPV分别为45%、36.36%、37.5%.PV、HPV的阳性表达与食管鳞癌具有显著相关(P＜0.05),正常食管黏膜组织中PV、HPV均为阴性.结果未发现PV、HPV阳性细胞与食管癌细胞分化程度有明显相关性(P＞0...
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| Published in | 肿瘤防治研究 Vol. 32; no. 1; pp. 46 - 48 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
430079,武汉,湖北省肿瘤研究所%湖北省肿瘤医院病理科%湖北钟祥柴湖乡卫生院
2005
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1000-8578 |
| DOI | 10.3971/j.issn.1000-8578.2005.01.018 |
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| Abstract | R735.1%R73-31; 目的探讨湖北钟祥河南移民与湖北本地居民食管鳞状细胞癌组织中人乳头状瘤病毒(human papillomavirus,HPV)感染的情况.方法应用免疫组化S-P方法,检测82例食管癌组织中PV和HPV感染情况.以正常食管手术残端黏膜组织作正常对照.结果钟祥食管癌高发区、麻城地区、湖北省肿瘤医院标本中PV阳性感染率分别为75%、68.18%、72.5%.HPV分别为45%、36.36%、37.5%.PV、HPV的阳性表达与食管鳞癌具有显著相关(P＜0.05),正常食管黏膜组织中PV、HPV均为阴性.结果未发现PV、HPV阳性细胞与食管癌细胞分化程度有明显相关性(P＞0.05).在三组研究对象之间PV、HPV的阳性率未显示统计学差异(P＞0.05).结论湖北钟祥河南移民及湖北其他地区居民食管癌组织中可能存在HPV感染.HPV在一定的地域环境中与食管癌发生、发展的关系可能具有普遍意义. |
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| AbstractList | R735.1%R73-31; 目的探讨湖北钟祥河南移民与湖北本地居民食管鳞状细胞癌组织中人乳头状瘤病毒(human papillomavirus,HPV)感染的情况.方法应用免疫组化S-P方法,检测82例食管癌组织中PV和HPV感染情况.以正常食管手术残端黏膜组织作正常对照.结果钟祥食管癌高发区、麻城地区、湖北省肿瘤医院标本中PV阳性感染率分别为75%、68.18%、72.5%.HPV分别为45%、36.36%、37.5%.PV、HPV的阳性表达与食管鳞癌具有显著相关(P＜0.05),正常食管黏膜组织中PV、HPV均为阴性.结果未发现PV、HPV阳性细胞与食管癌细胞分化程度有明显相关性(P＞0.05).在三组研究对象之间PV、HPV的阳性率未显示统计学差异(P＞0.05).结论湖北钟祥河南移民及湖北其他地区居民食管癌组织中可能存在HPV感染.HPV在一定的地域环境中与食管癌发生、发展的关系可能具有普遍意义. |
| Author | 姚品芳 李广灿 王瑞勤 夏和顺 杨小玲 付由高 沙聚伟 黄环元 王锡印 |
| AuthorAffiliation | 430079,武汉,湖北省肿瘤研究所%湖北省肿瘤医院病理科%湖北钟祥柴湖乡卫生院 |
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| DocumentTitle_FL | The Compare of HPV Infection in Esophageal Carcinoma in Henan Emigration of Hubei Zhongxiang and Hubei Native Residenter |
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| Keywords | 人乳头状瘤病毒 免疫组织化学 食管癌 |
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| Title | 湖北钟祥河南移民与湖北本地居民食管鳞状细胞癌组织中HPV感染的比较 |
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