Characterization of Salmonella endolysin XFII produced by recombinant Escherichia coli and its application combined with chitosan in lysing Gram-negative bacteria

• Published in: Microbial cell factories Vol. 21; no. 1; pp. 171 - 13
• Main Authors: Zhang, Shuhang, Chang, Yan, Zhang, Qing, Yuan, Yingbo, Qi, Qingsheng, Lu, Xuemei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 23.08.2022; BioMed Central; BMC
• Subjects: Animals; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics; Antiinfectives and antibacterials; Antimicrobial agents; Bacteria; Bacterial diseases; Bacterial infections; Bactericidal activity; Bacteriophages - genetics; Cell death; Chemical properties; Chitin; Chitosan; Chitosan - pharmacology; Cloning; Complications and side effects; Drug development; Drug resistance; E coli; Edetic Acid; Endolysin; Endopeptidases - genetics; Endopeptidases - metabolism; Endopeptidases - pharmacology; Enzymes; Escherichia coli; Escherichia coli - genetics; Escherichia coli - metabolism; Ethylenediaminetetraacetic acids; Eutrophic environments; Eutrophication; Food; Foodborne pathogens; Genomes; Gram-negative bacteria; Gram-Negative Bacteria - metabolism; Gram-negative pathogen; Gram-positive bacteria; Health aspects; Heat resistance; Heterologous expression; High temperature; Klebsiella; Lysis; Medical research; Microorganisms; Morphology; Pathogens; Phages; Pretreatment; Proteins; R&D; Rabbits; Research & development; Salmonella; Salmonella - genetics; Salmonella - metabolism; China; Endolysin; Salmonella; Chitosan; Gram-negative pathogen; Bactericidal activity; Heterologous expression

Salmonella is a common foodborne pathogen, which can cause intestinal diseases. In the last decades, the overuse of antibiotics has led to a pandemic of drug-resistant bacterial infections. To tackle the burden of antimicrobial resistant pathogens, it is necessary to develop new antimicrobial drugs...