Metal organic framework-coated gold nanorod as an on-demand drug delivery platform for chemo-photothermal cancer therapy

• Published in: Journal of nanobiotechnology Vol. 19; no. 1; pp. 219 - 13
• Main Authors: Huang, Junfeng, Xu, Zhourui, jiang, Yihang, Law, Wing-cheung, Dong, Biqin, Zeng, Xierong, Ma, Mingze, Xu, Gaixia, Zou, Jizhao, Yang, Chengbin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.07.2021; BioMed Central; BMC
• Subjects: Acids; Animals; Antimitotic agents; Antineoplastic agents; Biocompatibility; Biocompatible; Biocompatible Materials; Biodegradability; Biodegradation; Biomedical materials; Cancer; Cancer therapies; Chemotherapy; Controlled release; Coordination compounds; Dosage and administration; Doxorubicin; Doxorubicin - pharmacology; Drug delivery; Drug Delivery Systems; Drug Liberation; Drugs; Efficiency; Equipment and supplies; Fever; Gold; Gold - chemistry; Gold nanorod; Heat; HeLa Cells; Humans; Hyperthermia; I.R. radiation; In vivo methods and tests; Infrared lasers; Irradiation; Lasers; MCF-7 Cells; Metal Nanoparticles - chemistry; Metal organic framework; Metal-organic frameworks; Metal-Organic Frameworks - chemistry; Mice; Mice, Inbred BALB C; Mice, Nude; Morphology; Nanoparticles; Nanorods; Nanotubes - chemistry; Near infrared radiation; Neoplasms - drug therapy; Nitrates; Particle Size; Pharmaceutical Preparations; Pharmaceutical research; Phototherapy; Photothermal therapy; Photothermal Therapy - methods; Pore size; Production processes; Surface matching; Synergistic effect; Tumors; Vehicles; Zeolites; China; Metal organic framework; Photothermal therapy; Biocompatible; Drug delivery; Gold nanorod

Chemo-photothermal therapy based on nanoparticles has emerged as a promising strategy for cancer treatment. However, its therapeutic efficacy and application potential are largely subjected to the uncontrollability and biotoxicity of functional nanoplatforms. Herein, a novel biocompatible and biodeg...