Automatic clustering of white matter fibers in brain diffusion MRI with an application to genetics

• Published in: NeuroImage (Orlando, Fla.) Vol. 100; pp. 75 - 90
• Main Authors: Jin, Yan, Shi, Yonggang, Zhan, Liang, Gutman, Boris A., de Zubicaray, Greig I., McMahon, Katie L., Wright, Margaret J., Toga, Arthur W., Thompson, Paul M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.10.2014; Elsevier Limited
• Subjects: Adult; Algorithms; Atlases as Topic; Brain Mapping - methods; Diffusion; Diffusion Tensor Imaging - methods; Female; Fiber clustering; Genetic heritability; Genetics; HARDI; Humans; Label fusion; Male; Methods; Nerve Fibers, Myelinated; Population; Studies; Tractography; White Matter - anatomy & histology; Young Adult; Genetic heritability; Fiber clustering; HARDI; Label fusion; Tractography

To understand factors that affect brain connectivity and integrity, it is beneficial to automatically cluster white matter (WM) fibers into anatomically recognizable tracts. Whole brain tractography, based on diffusion-weighted MRI, generates vast sets of fibers throughout the brain; clustering them...